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THE JOURNAL OF CARDIOVASCULAR SURGERY

Rivista di Chirurgia Cardiaca, Vascolare e Toracica


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The Journal of Cardiovascular Surgery 2000 October;41(5):669-74

Copyright © 2009 EDIZIONI MINERVA MEDICA

lingua: Inglese

Effects of intra-aortic ballon pumping on renal sympathetic nerve activity and renal circulation in dogs

Tokunaga S., Tominaga R., Nakano T., Fukae K., Takeshita A., Yasui H.

From the Division of Cardiovascular Surgery and Division of Cardiovascular Clinic* Research Institute of Angiocardiology Kyushu University, Fukuoka, Japan


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Background. Little is ­known on how ­intra-aor­tic bal­loon pump­ing (­IABP) ­affects neu­ral cir­cu­la­to­ry reg­u­la­tion, ­even ­though ­many stud­ies ­have ­been ­done to clar­i­fy the ­effects of ­IABP on hemo­dy­nam­ics. Although ­IABP is ­used clin­i­cal­ly in ­patients ­with ­severe ­heart fail­ure, ­whose sym­pa­thet­ic ­nerve activ­ity is ­increased, ­there are no pre­vi­ous ­reports ­that dem­on­strate the ­effects of ­IABP on neu­ral reg­u­la­tion in ­heart fail­ure. The aim of ­this ­study is to deter­mine the ­effects of ­IABP on neu­ral reg­u­la­tion of ­renal cir­cu­la­tion ­with ­both nor­mal and fail­ing ­heart con­di­tion in ­dogs.
Methods. We direct­ly meas­ured ­renal sym­pa­thet­ic ­nerve activ­ity and hemo­dy­nam­ic param­e­ters (­heart ­rate, cen­tral ­venous pres­sure, dis­tal aor­tic pres­sure, prox­i­mal aor­tic pres­sure, ­left ven­tric­u­lar pres­sure, ­renal sym­pa­thet­ic ­nerve activ­ity, ascend­ing aor­tic ­flow, and ­renal arte­ri­al ­flow) ­before and dur­ing ­IABP driv­ing in ­both nor­mal and fail­ing ­heart con­di­tion in ­dogs (n=7). Acute ­heart fail­ure mod­els ­were ­made by cor­o­nary liga­tion.
Results. ­IABP driv­ing inhib­its ­renal sym­pa­thet­ic ­nerve activ­ity and ­improves ­renal cir­cu­la­tion in fail­ing ­heart con­di­tion, ­while ­these phe­nom­e­na do not ­occur in nor­mal ­heart con­di­tion.
Conclusions. These find­ings sug­gest ­that ­IABP may ­show its ­full ­effect on ­renal cir­cu­la­tion via neu­ral reg­u­la­tion espe­cial­ly in fail­ing ­heart con­di­tion.

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