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ULTIMO FASCICOLOTHE JOURNAL OF CARDIOVASCULAR SURGERY

Rivista di Chirurgia Cardiaca, Vascolare e Toracica


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The Journal of Cardiovascular Surgery 2000 Agosto;41(4):533-9

CARDIAC PAPERS 

 ORIGINAL ARTICLES

Effect of ATP-potassium channel opener nicorandil on long-term cardiac preservation

Hachida M., Lu H., Ohkado A, Gu H. *, Zhang X.-L., Furukawa H., Nakanishi T. *, Koyanagi H.

From the Department of Cardiovascular Surgery
*Department of Pediatric Cardiology The Heart Institute of Japan Tokyo Women’s Medical College Tokyo, Japan

Background. ATP-sen­si­tive potas­sium chan­nels ­have ­been ­shown to be one of the impor­tant pro­tec­tive mech­a­nisms for the ischem­ic myo­car­di­um. The pur­pose of ­this ­study was to eval­u­ate the pro­tec­tive ­effect of nic­o­ran­dil, an ATP-sen­si­tive potas­sium chan­nel open­er, on myo­car­di­um dur­ing 6 hours hypo­ther­mic pres­er­va­tion.
Methods. Preserved rat ­hearts ­were ran­dom­ly divid­ed ­into 4 ­groups accord­ing to car­di­o­ple­gia and pres­er­va­tion pro­to­cols as fol­lows: (1) his­ti­dine-tryp­to­phan-ket­o­glu­tar­ate solu­tion (HTK) for ­both car­di­o­pleg­ic and immers­ing solu­tions (­group A); (2) nic­o­ran­di­lad­ded HTK for car­di­o­pleg­ic solu­tion and nic­o­ran­dil-­free HTK for immers­ing solu­tion (­group B); (3) nic­o­ran­dil-­free HTK for car­di­o­pleg­ic solu­tion and nic­o­ran­dil-add­ed HTK for immers­ing solu­tion (­group C); and (4) nic­o­ran­dil-add­ed HTK for ­both car­di­o­pleg­ic and immers­ing solu­tions (­group D).
Results. The recov­ery of ­postischem­ic car­diac func­tion, includ­ing ­left ven­tric­u­lar devel­oped pres­sure and end-dia­stol­ic pres­sure, was sig­nif­i­cant­ly ­improved in ­group B and ­group C as com­pared ­with the oth­er ­groups (p<0.05). Postischem­ic intra­cel­lu­lar cal­cium con­cen­tra­tion was sig­nif­i­cant­ly low­er in ­group B and ­group C ­than in ­group A (p<0.05).
Conclusions. We con­clud­ed ­that nic­o­ran­dil-­induced hyper­po­lar­iz­ing ­arrest ­could ­reduce ische­mia-­derived myo­cyte inju­ry and inhib­it the ­influx of cal­cium ­into the myo­cy­tes in ­long-­term car­diac pres­er­va­tion.

lingua: Inglese


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