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THE JOURNAL OF CARDIOVASCULAR SURGERY
Rivista di Chirurgia Cardiaca, Vascolare e Toracica
Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
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ORIGINAL ARTICLES CARDIAC PAPERS
The Journal of Cardiovascular Surgery 1999 December;40(6):803-9
IL-8, IL-6 and ICAM-1 in serum of paediatric patients undergoing cardiopulmonary bypass with and without cardiocirculatory arrest
Antonelli M., Testa G.*, Tratapepe L., D'Errico R. R., Costa D.*, Giovannelli L.**, Riccioni L., Gasparetto A., Catena G.*
From the Department of Anaesthesia and Intensive Care, University “La Sapienza”, Rome, Italy
*Medical and Surgical Department of Pediatric Cardiology and **Transfusion Center “Bambino Gesù” Hospital, Rome, Italy
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Background. The aim of the present study was to evaluate the systemic inflammatory response to CPB in paediatric patients undergoing surgical correction of congenital heart diseases.
Methods. Experimental design: comparative investigation. Setting: paediatric cardiology hospital. Intervention: ICAM-1, IL-8, and IL-6 production were analysed before and during CPB, and after surgery in 9 paediatric patients, submitted to cardiocirculatory arrest (Group A); and in 11 without cardiocirculatory arrest (Group B). Measures: ICAM-1, IL-8, and IL-6 production were analysed from arterial samples before and during CPB, and after surgery.
Results. In group A vs group B a significant increase of IL-8 was detected during (297±250 vs 11±19 pg·ml-1, p<0.001) and after (100±230 vs n.d. pg·ml-1) surgery and was correlated with the duration of operation (r=0.759; p=0.0001) and clamping time (r=0.738; p<0.05). After surgery in group A, IL-6 levels (35±43 pg·ml) were higher than those in group B (2±5 pg·ml), and a good correlation was observed between IL-6 and duration of aortic clamping (r=0.714; p=0.048), cardiac arrest, (r=0.714; p=0.048), and length of surgery (r=0.867; p=0.04).
Conclusions. In children who underwent CPB with cardiocirculatory arrest cytokine production seems related to duration of operation and amplified by ischemia-reperfusion phenomena.