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Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,632
Online ISSN 1827-191X
Antonelli M., Testa G.*, Tratapepe L., D'Errico R. R., Costa D.*, Giovannelli L.**, Riccioni L., Gasparetto A., Catena G.*
From the Department of Anaesthesia and Intensive Care, University “La Sapienza”, Rome, Italy
*Medical and Surgical Department of Pediatric Cardiology and **Transfusion Center “Bambino Gesù” Hospital, Rome, Italy
Background. The aim of the present study was to evaluate the systemic inflammatory response to CPB in paediatric patients undergoing surgical correction of congenital heart diseases.
Methods. Experimental design: comparative investigation. Setting: paediatric cardiology hospital. Intervention: ICAM-1, IL-8, and IL-6 production were analysed before and during CPB, and after surgery in 9 paediatric patients, submitted to cardiocirculatory arrest (Group A); and in 11 without cardiocirculatory arrest (Group B). Measures: ICAM-1, IL-8, and IL-6 production were analysed from arterial samples before and during CPB, and after surgery.
Results. In group A vs group B a significant increase of IL-8 was detected during (297±250 vs 11±19 pg·ml-1, p<0.001) and after (100±230 vs n.d. pg·ml-1) surgery and was correlated with the duration of operation (r=0.759; p=0.0001) and clamping time (r=0.738; p<0.05). After surgery in group A, IL-6 levels (35±43 pg·ml) were higher than those in group B (2±5 pg·ml), and a good correlation was observed between IL-6 and duration of aortic clamping (r=0.714; p=0.048), cardiac arrest, (r=0.714; p=0.048), and length of surgery (r=0.867; p=0.04).
Conclusions. In children who underwent CPB with cardiocirculatory arrest cytokine production seems related to duration of operation and amplified by ischemia-reperfusion phenomena.