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THE JOURNAL OF CARDIOVASCULAR SURGERY
Rivista di Chirurgia Cardiaca, Vascolare e Toracica
Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
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ORIGINAL ARTICLES THORACIC PAPERS
The Journal of Cardiovascular Surgery 1999 October;40(5):741-8
FDG/PET and spiral CT image fusion for medistinal lymph node assessment of non-small cell lung cancer patients
Magnani P., Carretta A.*, Rizzo G., Fazio F., Vanzulli A.**, Lucignani G., Zannini P.*, Messa C., Lanconi C., Gilardi M. C., Del Maschio A.**
From the Department of Nuclear Medicine
*Department of Thoracic Surgery
**Department of Diagnostic Radiology
INB-CNR, Institute H. S. Raffaele University of Milan, Milan, Italy
Background. To assess the potential usefulness of
18F-FDG/PET and spiral-CT images concurrent assessment and coregistration in staging mediastinal lymph node involvement in patients with non small cell lung cancer.
Methods. 28 patients waiting to undergo surgical treatment underwent spiral-CT and PET examinations on the same day. The results of the two studies were interpreted separately, together (CT&PET) and following their fusion in a single image (CT+PET). Results of spiral-CT, PET, CT&PET and CT+PET were assessed with respect to the histological diagnosis.
Results. A correct assessment of mediastinal lymph nodes was achieved by spiral-CT in 21 of the 28 patients, in 22 of the 28 patients by PET, in 24 patients by CT&PET and in 25 patients by CT+PET.
Conclusions. CT+PET is more accurate than spiral-CT and PET alone in staging mediastinal lymph node involvement in lung cancer patients, with possible implications for their prognosis and therapy