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THE JOURNAL OF CARDIOVASCULAR SURGERY

Rivista di Chirurgia Cardiaca, Vascolare e Toracica


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The Journal of Cardiovascular Surgery 1999 April;40(2):279-80

lingua: Inglese

Repair of abdom­inal ­aortic aneu­rysm in ­severe ­Factor VII defi­ciency

Ferlan G., De Pasquale C., Testini M., Agnino A., D'Agostino D.

From the Divi­sion of Car­diac Sur­gery Faculty of Med­i­cine Uni­ver­sity of ­Bari, ­Bari, ­Italy


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Con­gen­ital ­Factor VII defi­ciency is a ­rare dis­order asso­ciated ­with ­reduced ­levels of ­Factor VII ­activity. Replace­ment ­therapy is nec­es­sary to con­trol hem­or­rhaging or if sur­gery is ­needed. We ­report oper­a­tive treat­ment of one ­case of ­chronic abdom­inal ­aortic aneu­rysm in a ­patient ­affected by a ­severe ­form of con­gen­ital ­Factor VII defi­ciency (endog­e­nous ­FVII ­level <1%). The oper­a­tion was car­ried out ­after the admin­is­tra­tion of ­Factor VII con­cen­trate ­raised the ­Factor VII con­cen­tra­tion to hemo­static ­levels. The ­patient con­tinued to ­receive the con­cen­trate ­every 6 hrs ­during the ­first ­three post­op­er­a­tive ­days. ­Dosage was ­assessed to ­obtain ­Factor VII ­levels not ­lower ­than 25%. No post­op­er­a­tive ­bleeding or throm­botic ­events ­were ­observed. The ­patient was dis­charged in excel­lent con­di­tion.

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