Home > Riviste > The Journal of Cardiovascular Surgery > Fascicoli precedenti > The Journal of Cardiovascular Surgery 1999 April;40(2) > The Journal of Cardiovascular Surgery 1999 April;40(2):211-6

ULTIMO FASCICOLO
 

ARTICLE TOOLS

Estratti

THE JOURNAL OF CARDIOVASCULAR SURGERY

Rivista di Chirurgia Cardiaca, Vascolare e Toracica


Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 2,179


eTOC

 

ORIGINAL ARTICLES  CARDIAC PAPERS


The Journal of Cardiovascular Surgery 1999 April;40(2):211-6

Copyright © 2000 EDIZIONI MINERVA MEDICA

lingua: Inglese

The diagnostic and prognostic value of cardiac Troponin T in bypass surgery

Simeone F., Biagioli B., Dolci A. *, Favilli R. **, Totaro P., Marullo A. ***, Giomarelli P. P., Toscano M.

From the Institute of Thoracic and Cardiovascular Surgery, Siena, Italy * Institute of Cardiology, University of Siena, Italy ** Department of Laboratory Medicine, H. S. Raffaele University of Milan, Italy *** Department of Experimental Medicine Cardiac Surgery University of L’Aquila, Italy


PDF  


Back­ground. The pur­pose of ­this ­study was to ­verify the ­utility of ­serum Tro­ponin T (TnT) in the diag­nosis of myo­car­dial ­damage ­after cor­o­nary sur­gery per­formed ­using dif­ferent ­methods of myo­car­dial pro­tec­tion. The prog­nostic ­value of TnT ­peak for a ­poor post­op­er­a­tive ­course was ­also inves­ti­gated.
­Methods. ­Forty-­three ­patients ­were ­enrolled and ran­dom­ised in 2 ­group: ­Group A (n. 22) ­receiving ­warm ­blood car­di­o­plegia and ­Group B (n. 21) ­receiving ­cold ­blood car­di­o­plegia. ­According to TnT ­peak ­levels 3 sub­groups ­were iden­ti­fied: Sub­group 1 (TnT ­peak < ­than 1 ng/ml); Sub­group 2 (TnT ­peak ­between 1 and 3 ng/ml), Sub­group 3 (TnT ­peak >3 ng/ml). A com­par­ison ­with the stan­dard cri­teria for diag­nosis of myo­car­dial ­ischemia was per­formed for ­each sub­group of ­patients. A 12 ­months ­follow-up for the ­patients of sub­groups 1 and 2 was ­also com­pleted in ­order to eval­uate the prog­nostic ­value of a ­higher TnT ­peak.
­Results. The ­overall ­patients sub­di­vi­sion in sub­group 1, 2 and 3 was 20 (46.5%), 14 (32.5%) and 9 (20.9%) respec­tively ­with no sta­tis­tical dif­fer­ence for ­Group A or B. ­Only 7 of the ­patients of sub­group 3 (87%) ­matched the WHO diag­nostic cri­teria for myo­car­dial infarc­tion. At the ­overall ­follow-up, 2 (14.28%) ­patients of sub­group 2, and 4 (20.0%) of sub­group 3, ­revealed a ­residual ­ischemia at the ECG-­stress ­test ­even if ­none of ­these ­needed reop­er­a­tion.
Con­clu­sions. Our ­data con­firmed the ­high sen­si­tivity and spec­i­ficity of TnT meas­ure­ment in the diag­nosis of myo­car­dial infarc­tion and ­minor myo­car­dial ­damage. ­This ­study, how­ever, ­failed to ­show any sta­tis­ti­cally sig­nif­i­cant dif­fer­ence of the TnT ­peak ­when ­using dif­ferent strat­e­gies of myo­car­dial pro­tec­tion. The ­late prog­nostic ­value of the TnT ­increase in the ­early post­op­er­a­tive ­course has to be con­firmed ­from a fur­ther ­study.

inizio pagina

Publication History

Per citare questo articolo

Corresponding author e-mail