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Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,632
Online ISSN 1827-191X
Charitos Ch. E., Nanas J. N., Nanas S. N., Chatzigeorgiou I., Alevizakos N., Cosmas K., Moulopoulos S. D.
From the Department of Clinical Therapeutics University of Athens, Medical School, Athens, Greece
Objective. To investigate the possible mechanisms of right and left ventricular interaction during ventricular fibrillation (VF) with mechanical maintenance of the circulation.
Experimental design. In this experimental study, two para-aortic counterpulsation devices (PACDs) were implanted in 14 mongrel dogs.
Setting. The PACD is a spheroid, valveless, with one opening, 100 ml stroke volume assisting device. After midsternotomy and pericardiotomy, two PACDs were implanted on the ascending aorta and the pulmonary artery, respectively. Catheters were placed into the aortic arch, and the left and right ventricles. An electromagnetic probe was placed on the descending aorta.
Interventions. After the completion of the experimental preparation, VF was induced and the two devices were synchronized and pumped simultaneously for 10 minutes (A). Subsequently, the left sided PACD pumped alone for the same period of time (B). This sequence was repeated 1-10 times in each experiment.
Measures. The aortic pressures, the left and right ventricular pressures and the cardiac index were obtained at the end of each intervention.
Results. The simultaneous pumping of the two devices (A) compared with the pumping of that implanted on the ascending aorta (B) resulted in: higher peak aortic pressure 119.1±32.1 mmHg (A) vs 105.7±36.4 mmHg (B), p<0.001, mean aortic pressure 42.1±13.2 mmHg vs 27.8±10.5 mmHg, p<0.001, mean left ventricular pressure 18.4+4.0 mmHg vs 11.7±3.6 mmHg, p<0.001, and cardiac index 105.7±40.1 ml/kg/min vs 82.0±39.9 ml/kg/mm, p<0.001, and lower right ventricular pressure 10.1±3.2 mmHg vs 13.3±2.6 mmHg, p<0.001.
Conclusions. Maintenance of the circulation during VF with the PACD implanted on the ascending aorta results in equalization of the right and left ventricular pressures. In contrast, when both devices are pumping simultaneously, the left ventricular pressure is significantly higher than the right one and the assistance is more effective.