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Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,632
Online ISSN 1827-191X
Hirose Y., Takamiya M.
From the Department of Radiology, National Cardiovascular Center, Osaka, Japan
Objective. We hypothesized that the aortic aneurysm might grow biexponentially. The object of this study was to determine the biexponential growth curve of aortic aneurysm.
Design. A fifteen-year retrospective review of CT images of aortic aneurysm.
Setting. Major cardiovascular referral center.
Patients. Patients with true aortic aneurysm who were followed up with CT and performed CT at their aneurysmal ruptures.
Measures. The largest short-axial diameters of the outer contour of the aneurysms were measured. Aortic aneurysmal diameters were normalized by those at ruptures, and the plots were fitted to the biexponential curve.
Results. Eight patients out of 1481 had been followed up with CT scans. In regression analysis, the values fit well to the biexponential equation: d(t) = 0.8345 exp (0.0052 t) + 0.1653 exp (0.8275 t), r = 0.934 where d(t) is the normalized diameter, and t is months before rupture. The first part of the equation mainly expresses the slow growth, and the second expresses the rapid growth shortly before rupture.
Conclusions. Aortic aneurysm began to grow faster at about three months before rupture. It is important to find out the point that the growth of aortic aneurysm changes its rate faster than before, and once the point is observed, elective repair should be considered.