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ITALIAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY

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Giornale Italiano di Chirurgia Vascolare 2002 December;9(4):323-46

Copyright © 2003 EDIZIONI MINERVA MEDICA

language: English, Italian

Biochemical aspects of carotid artery plaque

Terzuoli L. 1, Marinello E. 1, Frosi B. 1, Cinci G. 1, Guerranti R. 1, Giubbolini R. 2, Setacci C. 2, Porcelli B. 1

1 Institute of Biochemistry and Enzymology 2 School and O.U. Vascular Surgery University of Siena, Siena


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Back­ground. The pur­pose of ­this ­study was to ­examine and quan­tify a ­series of bio­chem­ical param­e­ters (pro­teins, ­nucleic ­acids, hypox­an­thine, xan­thine, ­uric ­acid, allan­toin, ­free rad­i­cals, elec­tro­lytes, ­lipids and ­fatty ­acids) in ­carotid ath­e­rom­a­tous ­plaque. ­Some of ­these sub­stances ­were com­pared ­with the cor­re­sponding ­plasma ­values.
­Methods. ­Carotid ­artery ­plaque sam­ples and ­plasma sam­ples ­were ­obtained ­from 95 sub­jects (76 ­male, 80% and 19 ­female, 20%) of ­average age 73 ­years (73±5 ­years) sub­jected to ­carotid throm­boen­dar­te­riec­tomy. Forty-six of ­these sub­jects ­were symp­to­matic and 49 asymp­to­matic. Sten­osis <70% was ­present in 46 ­patients ­while in 49 sten­osis was ≥70%. The ­plaque was char­ac­ter­ised mor­pho­log­i­cally by ­echo ­color-Dop­pler. The ­methods ­adopted, and at ­times mod­i­fied, for the extrac­tion and quan­ti­ta­tive anal­ysis of the var­ious bio­chem­ical param­e­ters ana­lysed, ­starting ­from ­often ­only ­small quan­tities of ­plaque, are ­described.
­Results. The ­results ­showed ­that ­plaque ­presents var­ious sig­nif­i­cant dif­fer­ences in var­ious metab­olites ­that are not ­always ­related to the clin­ical ­data.
Con­clu­sions. ­Even ­though at the ­moment it is not pos­sible to ­reach defin­i­tive con­clu­sions, of all the sub­stances ana­lysed the param­e­ters for oxi­da­tive ­stress and the ­study of ­nucleic ­acids and pro­teoma are the ­most prom­ising and inter­esting ­fields for char­ac­ter­ising ­plaque “at ­risk”.

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