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A Journal on Vascular and Endovascular Surgery

Official Journal of the Italian Society of Vascular and Endovascular Surgery
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Giornale Italiano di Chirurgia Vascolare 1999 March;6(1):35-44

language: English, Italian

Helicobacter pylo­ri and sis­tem­ic arte­ri­al dis­ease. Does a cor­re­la­tion ­exist?

Raso A. M., Sandrone N., Maselli M., Pellicano R. *, Ponzetto A. *

From the Department of Medical and Surgical Sciences University of Tutir, Turin, University Vascular Surgery Unit, Turin,
* Gastroenterology Unit, Ospedale Molinette, Turin, Italy


Background and ­aims. Helicobacter pylo­ri (HP) infec­tion induc­es a chron­ic inflam­ma­to­ry ­response at var­i­ous lev­els, includ­ing the vas­cu­lar ­system; oth­er stud­ies ­have ­shown ­this ­kind of rela­tion­ship ­between HP and cor­o­nary ­heart dis­ease, ­acute myo­car­dial infarc­tion, elec­tro­car­di­o­graph­ic alter­a­tions and Raynaud’s phe­nom­e­non. In the ­light of ­these find­ings, we ­tried to ­find a ­link ­between HP infec­tion and periph­er­al arte­ri­al dis­ease.
Methods. The ­study includ­ed 107 ­patients suf­fer­ing ­from arte­ri­al dis­ease hos­pit­al­ised in our depart­ment. These ­patients (69 ­males and 38 ­females) ­were sub­mit­ted to rou­tine ­blood ­tests and ­were test­ed for the pres­ence of ser­um anti­bod­ies ­against HP; the ­data ­obtained ­were com­pared to cor­re­spond­ing ­results ­from the exam­ina­tion of 610 ran­dom­ised ­blood ­donors at our hos­pi­tal (89 ­females and 521 ­males). We divid­ed all the ­patients test­ed for anti­bod­ies ­against HP ­into six age class­es (18-27 ­years old, 28-37 yrs, 38-57 yrs, 58-69 yrs, >70 yrs). All ­patients ­were ­checked for the fre­quen­cy of HP pos­i­tiv­ity in the ­main vas­cu­lar dis­eas­es (AAA, carot­id sten­o­sis, chron­ic periph­er­al arte­ri­al occlu­sion, oth­er). Moreover, the cor­re­la­tion ­between HP pos­i­tiv­ity and gas­trod­u­od­en­al pathol­o­gy was eval­u­at­ed, as ­well as the per­cent­age of pos­i­tiv­ity in rela­tion to the ­main ath­e­ros­cle­rot­ic ­risk fac­tors (­white ­blood ­count, ­total cho­les­te­rol, fibrino­gen, smok­ing, dia­betes, hyper­ten­sion).
Results. Altogether our ­patients had a per­cent­age of pos­i­tiv­ity to HP of 77.57% ver­sus 48.88% ­observed ­among ­blood ­donors (PV=0.001).
Conclusions. The ­high pos­i­tive per­cent­age of HP anti­bod­ies ­observed in ­patients ­with vas­cu­lar dis­eas­es under­lines an impor­tant rela­tion­ship. Further ­research is ­required ­both to estab­lish an etio­path­o­log­i­cal ­link and to iden­ti­fy new ther­a­peu­tic approach­es, in the ­same way as for cor­o­nary ­heart dis­ease.

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