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ITALIAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
A Journal on Vascular and Endovascular Surgery
Giornale Italiano di Chirurgia Vascolare 1999 March;6(1):35-44
language: English, Italian
Helicobacter pylori and sistemic arterial disease. Does a correlation exist?
Raso A. M., Sandrone N., Maselli M., Pellicano R. *, Ponzetto A. *
From the Department of Medical and Surgical Sciences University of Tutir, Turin, University Vascular Surgery Unit, Turin,
* Gastroenterology Unit, Ospedale Molinette, Turin, Italy
Background and aims. Helicobacter pylori (HP) infection induces a chronic inflammatory response at various levels, including the vascular system; other studies have shown this kind of relationship between HP and coronary heart disease, acute myocardial infarction, electrocardiographic alterations and Raynaud’s phenomenon. In the light of these findings, we tried to find a link between HP infection and peripheral arterial disease.
Methods. The study included 107 patients suffering from arterial disease hospitalised in our department. These patients (69 males and 38 females) were submitted to routine blood tests and were tested for the presence of serum antibodies against HP; the data obtained were compared to corresponding results from the examination of 610 randomised blood donors at our hospital (89 females and 521 males). We divided all the patients tested for antibodies against HP into six age classes (18-27 years old, 28-37 yrs, 38-57 yrs, 58-69 yrs, >70 yrs). All patients were checked for the frequency of HP positivity in the main vascular diseases (AAA, carotid stenosis, chronic peripheral arterial occlusion, other). Moreover, the correlation between HP positivity and gastroduodenal pathology was evaluated, as well as the percentage of positivity in relation to the main atherosclerotic risk factors (white blood count, total cholesterol, fibrinogen, smoking, diabetes, hypertension).
Results. Altogether our patients had a percentage of positivity to HP of 77.57% versus 48.88% observed among blood donors (PV=0.001).
Conclusions. The high positive percentage of HP antibodies observed in patients with vascular diseases underlines an important relationship. Further research is required both to establish an etiopathological link and to identify new therapeutic approaches, in the same way as for coronary heart disease.