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A Journal on Vascular and Endovascular Surgery

Official Journal of the Italian Society of Vascular and Endovascular Surgery
Indexed/Abstracted in: EMBASE, Scopus



Giornale Italiano di Chirurgia Vascolare 1998 September;5(3):141-9

language: English, Italian

Importance of lip­id and non lip­id fac­tors in extra­cra­ni­al carot­id ather­o­gen­e­sis

Ercolini L., Chiti E., Terreni A., Anichini M., Cesaretti S., Lepori M., Pratesi C.

From the Department of Vascular Surgery University of Florence INR­CA Istituto di Analisi, Florence, Italy


Background and aim. The ­study ­aimed to eval­u­ate the impor­tance of lip­id and non-lip­id fac­tors in the path­o­gen­e­sis of carot­id sten­o­sis.
Methods. A ­total of 342 carot­id endar­te­rec­to­mies ­were per­formed in 1997 ­from ­which 48 con­sec­u­tive cas­es ­were ­enrolled to ­form the ­study ­group; a con­trol ­group of 40 cas­es was ­also stud­ied. Cholesterol, tri­gly­ce­rides, HDL, LDL, ­VLDL, lip­o­pro­tein (a), homo­cys­teine and anti­bod­ies ­against oxid­ised LDL ­were eval­u­at­ed in ­each ­patient. The ­mean and stan­dard devi­a­tion ­were cal­cu­lat­ed for ­each param­e­ter; sta­tis­ti­cal anal­y­sis and var­i­ance anal­y­sis ­were per­formed and p was con­sid­ered sig­nif­i­cant if <0.005. The ­study ­took the ­form of a pros­pec­tive, com­par­a­tive and ran­dom­ised ­case/ con­trol ­study.
Results. Only cho­les­te­rol was ­found to be high­er in con­trols: 232.7 mg/dl vs 196.9 mg/dl (p=0.001). HDL lev­els ­were 47.1 mg/dl in con­trols vs 38.1 mg/dl (p=0.002). Lipoprotein (a) in the ­first ­group was 46.6 mg/dl vs 36.2 mg/dl in con­trols (p=0.0004). Homocysteine was 8.1 μM/L in the ­study ­group and 6.6 μM/L in con­trols (p=0.003). Antibodies ­against oxid­ised LDL ­were 188.4 mU/ml in ­patients under­go­ing sur­gery and 150.1 mU/ml in con­trols (p=0.002).
Conclusions. The ­authors ­found sta­tis­ti­cal­ly sig­nif­i­cant dif­fer­enc­es ­between non-lip­id fac­tors in ­both ­groups and non-sig­nif­i­cant dif­fer­enc­es ­between the clas­sic lip­id fac­tors. Further ­research is ­required in ­order to con­firm ­these ­results, ­also tak­ing ­account of the reper­cus­sions of the non-sur­gi­cal treat­ment of carot­id sten­o­sis.

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