Home > Journals > The Journal of Sports Medicine and Physical Fitness > Past Issues > Articles online first > The Journal of Sports Medicine and Physical Fitness 2016 Sep 13





A Journal on Applied Physiology, Biomechanics, Preventive Medicine,
Sports Medicine and Traumatology, Sports Psychology

Indexed/Abstracted in: Chemical Abstracts, CINAHL, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,111



The Journal of Sports Medicine and Physical Fitness 2016 Sep 13

language: English

Acute supplementation of L-arginine neither affects strength performance nor nitric oxide production

Claudia M. MEIRELLES 1, Cristiane MATSUURA 2

1 Section of Graduate Programs, School of Physical Education of Army, Rio de Janeiro, Brazil; 2 Department of Pharmacology and Psychobiology, State University of Rio de Janeiro, Brazil


BACKGROUND: L-arginine is a semi-essential amino acid involved in nitric oxide production. As nitric oxide is an important vasodilator, L-arginine supplementation would increase blood perfusion and, subsequently, muscle performance during exercises. The aim of this study was to determine the acute effect of L-arginine supplementation on strength performance and nitric oxide levels in healthy trained individuals.
METHODS: In a doubleblind, placebo-controlled, cross-over study, 12 men were randomly assigned to L-arginine or placebo supplementation. Subjects received 6 g of L-arginine or placebo 60 min before strength test (maximum number of repetitions, 3 sets at 70% of one repetition maximum on bench press and at 80% of one repetition maximum on knee extensions, 2 min of rest between sets and exercises). Blood samples were collected before supplementation and 6 min after exercise.
RESULTS: Plasma nitrite levels did not significantly change after Larginine or placebo supplementation and strength-training exercise (placebo, from 13.01 ± 1.18 to 11.83 ± 2.81 mM; L-arginine, from 10.95 ± 4.09 to 11.99 ± 2.5 mM). There was a significant reduction in the number of repetitions performed from set 1 to set 3 in each set of both bench press and knee extension, but no significant interactions were observed between placebo and L-arginine.
CONCLUSIONS: These results do not support the use of L-arginine as an ergogenic aid for strength performance, at least in context of acute use immediately before resistance exercise performance.

top of page

Publication History

Cite this article as

Corresponding author e-mail