Total amount: € 0,00
Indexed/Abstracted in: Chemical Abstracts, CINAHL, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,111
Online ISSN 1827-1928
Fabio Santos LIRA 1, Valdir DE AQUINO LEMOS 2, 3, Irene Guarido BITTAR 2, Aline Venticinque CARIS 4, Ronaldo Vagner DOS SANTOS 4, Sergio TUFIK 2, Alessandro MOURA ZAGATTO 5, Cláudio Teodoro DE SOUZA 6, Gustavo Duarte PIMENTEL 7, Marco Tulio DE MELLO 2, 3
1 Exercise and Immunometabolism Research Group, Department of Physical Education, Universidade Estadual Paulista, UNESP, Presidente Prudente, SP, Brazil; 2 Departamento de Psicobiologia, Campus São Paulo, Universidade Federal de São Paulo, UNIFESP, Brazil; 3 Centro de Estudos em Psicobiologia e Exercício, CEPE, São Paulo, Brazil; 4 Departamento de Biociências, Campus da Baixada Santista, Universidade Federal de Sao Paulo, UNIFESP, Brazil; 5 Departamento de Educação Fisica, Faculdade de Ciências, Universidade Estadual Paulista, UNESP, Campus de Bauru; 6 Laboratory of Exercise Biochemistry and Physiology, Postgraduate Program in Health Sciences, Health Sciences Unit, Universidade do Extremo Sul Catarinense, Criciúma, SC, Brazil; 7 Laboratório de Investigação em Nutrição Clínica e Esportiva Labince, Faculdade de Nutrição, Universidade Federal de Goiás, Goiânia, Brazil
BACKGROUND: Studies have demonstrated that exercise in hypoxia situations induces a cytotoxicity effects. However, the cytokines participation in this condition is remaining unknown. Thus, the aim the present study was to evaluate physiological parameters and inflammatory profiles in response to acute exercise after five hours of hypoxic conditions.
METHODS: Fourteen healthy men were distributed randomly into two groups: normoxic exercise (n=7) and hypoxic exercise (n=7). All volunteers were blinded to the protocol.
Initially, all subjects were submitted to chamber normobaric in a room fitted for altitude simulations of up to 4,500 m, equivalent to a barometric pressure of 433 mmHg. All analyses began at 7:00 a.m. and was maintained for 5 hours; the fraction of inspired oxygen (FiO2) was 13.5%. The groups began a 60 minute session of physical exercise starting at 11:00 a.m., at 50% of peak VO2 (50%VO2 peak). Blood was collected for cytokine analysis in the morning upon waking, before the 60 minute exercise session and immediately thereafter.
RESULTS: The heart rate during ET60 min was significantly increased in both exercise groups (p<0.05), and the oxygen saturation was reduced under hypoxic conditions during exercise (p<0.05). After exercise, significant increases were found for IL-1ra and IL-10 under hypoxic conditions (p<0.05) and for IL-6 for both groups (p<0.05). TNF-α was not altered under either environmental condition.
CONCLUSION: Our data demonstrate that acute exercise performance in hypoxic conditions can promotes early inflammatory response, leads for immunosuppression state.