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A Journal on Applied Physiology, Biomechanics, Preventive Medicine,
Sports Medicine and Traumatology, Sports Psychology

Indexed/Abstracted in: Chemical Abstracts, CINAHL, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
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The Journal of Sports Medicine and Physical Fitness 2014 Sep 22

language: English

Multi center cohort study on association of genotypes with prospective sports concussion: methods, lessons learned, and recommendations

Terrell T. R. 1, Abramson R. 1, Bostick R. 2, Barth J. 3, Sloane R. 4, Cantu R. C. 5, Bennett E. 6, Galloway L. 7, Erlanger D. 8, McKeag D. 9, Valentine V. 10, Nichols G. 11

1 University of Tennessee Graduate School of Medicine, Department of Family Medicine, Knoxville, TN;
2 Emory University, School of Public Health, Department of Epidemiology, Atlanta, GA, USA;
3 Department of Psychiatry, Center for Study of Sports TBI, Director, Neuropsychology Service, University of Virginia School of Medicine, Charlottesville, VA;
4 Duke University Center for the Study of Aging and Human Development, Duke University Medical, Center Durham, NC Durham, NC;
5 Boston University School of Medicine, Boston MA; Center for the Study of Chronic Traumatic Encephalopathy, Boston, MA;
6 Duke University School of Medicine, Department of Medicine (Neurology), Durham, NC;
7 Oak Ridge National Laboratory, Oak Ridge, TN Daniel Laskowitz, MD, MS, Duke University School of Medicine, Department of Medicine (Neurology) and Anesthesiology, Durham, NC;
8 Mount Sinai School of Medicine, New York, NY;
9 University of Indiana School of Medicine, Department of Family Medicine, Indianapolis, IN;
10 Sanford School of Medicine of the University of South Dakota, Sioux Falls, SD; Sanford Orthopedics & Sports Medicine, Sioux Falls, SD;
11 University of Tennessee Graduate School of Medicine, Knoxville, TN


This was a multicenter prospective cohort study designed to investigate a potential association between genetic polymorphisms of apolipoprotein E gene, apolipoprotein E promoter G219T, and two Tau gene exon 6 polymorphisms (Ser53Pro and Hist47Tyr) with: (1) the risk of prospective concussion, (2) concussion severity, and (3) postconcussion neurocognitive recovery. Almost three thousand student athletes from 26 National Collegiate Athletic Association Division IA, II, III, and National Association of Intercollegiate Athletics academic institutions in the United States met inclusion criteria for this study. We assessed multiple variables including, gender, sport, family history of traumatic brain injury, history of mental illness, history of migraine headache, and baseline and postconcussion neuropsychological test results. Reported concussions were evaluated with multiple instruments including number of symptoms and symptom severity. Additionally, we gathered data via a questionnaire pertaining to medical history, demographics, and sportrelated information, and blood/saliva samples were collected for genetic analysis, and we conducted neuropsychological testing using Headminder and ImPACT software. The goal of this paper is to share our experiences conducting a large prospective cohort study. We recommend that future research include metaanalyses of various traumatic brain injury studies to increase power. Collaborative research is very likely needed given the nature of this study population.

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