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THE JOURNAL OF SPORTS MEDICINE AND PHYSICAL FITNESS

A Journal on Applied Physiology, Biomechanics, Preventive Medicine,
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ORIGINAL ARTICLE  EPIDEMIOLOGY AND CLINICAL MEDICINE


The Journal of Sports Medicine and Physical Fitness 2017 April;57(4):461-8

DOI: 10.23736/S0022-4707.16.06073-X

Copyright © 2016 EDIZIONI MINERVA MEDICA

language: English

Physiological and cytokine response to acute exercise under hypoxic conditions: a pilot study

Fábio S. LIRA 1 , Valdir A. LEMOS 2, 3, Irene G. BITTAR 2, Aline V. CARIS 4, Ronaldo V. dos SANTOS 4, Sergio TUFIK 2, Alessandro M. ZAGATTO 5, Claudio T. de SOUZA 6, Gustavo D. PIMENTEL 7, Marco T. De MELLO 2, 3, 8

1 Exercise and Immunometabolism Research Group, Department of Physical Education, São Paulo State University (UNESP), Presidente Prudente, Brazil; 2 Department of Psychobiology, São Paulo Federal University (UNIFESP), São Paulo, Brazil; 3 Center for Studies in Psychobiology and Physical Exercise (CEPE), São Paulo, Brazil; 4 Department of Biosciences, São Paulo Federal University (UNIFESP), Santos, Brazil; 5 Department of Physical Education, Faculty of Sciences, São Paulo State University (UNESP), Bauru, Brazil; 6 Laboratory of Exercise Biochemistry and Physiology, Health Sciences Unit, University of the Extreme South of Santa Catarina, Criciúma, Brazil; 7 Laboratory for Investigation on Clinical and Sports Nutrition (Labince), Faculty of Nutrition, Federal University of Goiás, Goiânia, Brazil; 8 Sports Department, Federal University of Minas Gerais, Belo Horizonte, Brazil


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BACKGROUND: Studies have demonstrated that exercise in hypoxia situations induces a cytotoxicity effects. However, the cytokines participation in this condition is remaining unknown. Thus, the aim the present study was to evaluate physiological parameters and inflammatory profiles in response to acute exercise after five hours of hypoxic conditions.
METHODS: Fourteen healthy men were distributed randomly into two groups: normoxic exercise (N.=7) and hypoxic exercise (N.=7). All volunteers were blinded to the protocol. Initially, all subjects were submitted to chamber normobaric in a room fitted for altitude simulations of up to 4500 m, equivalent to a barometric pressure of 433 mmHg. All analyses began at 7:00 a.m. and was maintained for 5 hours; the fraction of inspired oxygen (FiO2) was 13.5%. The groups began a 60-minute session of physical exercise starting at 11:00 a.m., at 50% of peak VO2 (50% VO2peak). Blood was collected for cytokine analysis in the morning upon waking, before the 60-minute exercise session and immediately thereafter.
RESULTS: The heart rate during 60 minutes’ exercise training was significantly increased in both exercise groups (P<0.05), and the oxygen saturation was reduced under hypoxic conditions during exercise (P<0.05). After exercise, significant increases were found for IL-1ra and IL-10 under hypoxic conditions (P<0.05) and for IL-6 for both groups (P<0.05). TNF-α was not altered under either environmental condition.
CONCLUSIONS: Our data demonstrate that acute exercise performance in hypoxic conditions can promotes early inflammatory response, leads for immunosuppression state.


KEY WORDS: Hypoxia - Exercise - Cytokines

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Publication History

Issue published online: February 21, 2017
Article first published online: January 21, 2016
Manuscript accepted: January 15, 2016
Manuscript revised: December 22, 2015
Manuscript received: August 10, 2015

Cite this article as

Lira FS, Lemos VA, Bittar IG, Caris AV, dos Santos RV, Tufik S, et al. Physiological and cytokine response to acute exercise under hypoxic conditions: a pilot study. J Sports Med Phys Fitness 2017;57:461-8. DOI: 10.23736/S0022-4707.16.06073-X

Corresponding author e-mail

fabiolira@fct.unesp.br