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THE JOURNAL OF SPORTS MEDICINE AND PHYSICAL FITNESS
A Journal on Applied Physiology, Biomechanics, Preventive Medicine,
Sports Medicine and Traumatology, Sports Psychology
Indexed/Abstracted in: Chemical Abstracts, CINAHL, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,111
ORIGINAL ARTICLES EPIDEMIOLOGY AND CLINICAL MEDICINE
The Journal of Sports Medicine and Physical Fitness 2016 January-February;56(1-2):100-4
Changes to circulating inflammatory cytokines in response to moderate exercise
Nicolás GÓMEZ-BANOY 1 , Ismena MOCKUS 1, Luz H. ARANZÁLEZ 1, Juan M. ZAMBRANO 2 ✉
1 Lipids and Diabetes Laboratory, Department of Physiological Sciences, Faculty of Medicine, National University of Colombia, Bogotá, Colombia; 2 Faculty of Engineering, University of Los Andes, Bogotá, Colombia
BACKGROUND: Regular physical activity improves the metabolic profile of patients, although the biological mechanisms involved are not clear yet. The anti-inflammatory effects of exercise are well known and are possibly related to its therapeutic properties. The aim of this study was to compare changes in the concentration of an anti-inflammatory cytokine — tumor necrosis factor soluble receptor-1 (sTNFR1) — and a pro-inflammatory cytokine — interleukin-1β (IL-1β) — during moderate physical exercise in sedentary versus athletic men.
METHODS: We analyzed serum inflammatory cytokine concentrations in 5 athletes and 5 sedentary men (aged 18 to 22): 1) 15 minutes and immediately before a 28-minute specifically-programmed moderate exercise session; 2) every 3 minutes during the exercise session; 3) 15 and 30 minutes after session completion.
RESULTS: We obtained serum sTNFR1 and IL-1β concentrations in 10 individuals. Both cytokines exhibited changes in their concentration during physical exercise: a significant increase in the concentration of sTNFR1 was observed in both the sedentary (P=0.0249) and the athlete (P=0.02172) groups. The levels of sTNFR1 were higher in the athlete group than in the sedentary group. No differences were observed in the IL-1β concentrations between the two groups.
CONCLUSIONS: Serum concentration of the anti-inflammatory cytokine sTNFR1 increased during moderate physical exercise, and its levels were higher in athletes before, during and after physical activity. These findings are consistent with previous findings concerning the anti-inflammatory properties of exercise, and suggest that sTNFR1 has an important role in the anti-inflammatory environment following physical activity.