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THE JOURNAL OF SPORTS MEDICINE AND PHYSICAL FITNESS
A Journal on Applied Physiology, Biomechanics, Preventive Medicine,
Sports Medicine and Traumatology, Sports Psychology
Indexed/Abstracted in: Chemical Abstracts, CINAHL, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,111
Original articles BODY COMPOSITION, SPORT NUTRITION AND SUPPLEMENTATION (ergogenics)
The Journal of Sports Medicine and Physical Fitness 2006 March;46(1):84-9
The effects of a nucleotide supplement on salivary IgA and cortisol after moderate endurance exercise
McNaughton L. 1, Bentley D. J. 2, Koeppel P. 3
1 Department of Sport and Exercise Science University of Hull, Hull, UK
2 Centre for Sport and Exercise Science Westminster University, London, UK
3 Probio Ltd., Augst, Switzerland
Aim. The aim of this work was to determine the ergogenic effects of a nucleotide supplement on salivary immunoglobulin A (SIgA) and cortisol (C) responses after prolonged endurance cycle exercise.
Methods. Fourteen moderately trained male subjects (mean body mass and V.O2max) completed 2 90-min cycle ergometer trials (60% V.O2max) prior to and after 60 days of either a nucleotide (E group, n=7) or placebo (P group, n=7) supplement. Each of the subjects provided an unstimulated saliva sample prior to and following the exercise for determination of SIgA and C.
Results. SIgA was significantly lower after exercise trials in both E and P groups (P<0.0001) prior to as well as after the supplementation period. However, SIgA was significantly higher (P<0.01) in the E group than the P group after supplementation. There were no significant (P>0.11) differences in pre-exercise C level. Postexercise C concentrations were significantly (P<0.001) higher than pre-exercise levels in both groups of subjects. However, after the supplementation period, C concentration was significantly (P<0.0001) lower after exercise in E compared to P.
Conclusion. This work suggests that a nucleotide supplement, given chronically may offset the hormonal response associated with demanding endurance exercise.