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Original articles  EPIDEMIOLOGY AND CLINICAL MEDICINE


The Journal of Sports Medicine and Physical Fitness 2003 September;43(3):393-7

language: English

Treadmill exercise increases cell proliferation in hippocampal dentate gyrus in alcohol-intoxicated rats

Yu B. K. 1, Yoon B. C. 2, Kim S. S. 2, Chun S. L. 3, Kim E. H. 4, Kim K. M. 5, Lim B. V. 5, Jang M. H. 5, Chung J. H. 5, Kim C. J. 5

1 Depart­ment of Phys­ical ­Therapy, Shingu Col­lege, ­Kyonggi, ­Korea
2 Research Insti­tute of ­Sports Sci­ence, Korea Uni­ver­sity, ­Seoul, ­Korea
3 Grad­uate ­School of ­Health Sci­ence, Col­lege of Med­i­cine, ­Pochun CHA Uni­ver­sity, ­Seoul, ­Korea
4 Depart­ment of Mer­i­di­a­nology, Col­lege of ­Oriental Med­i­cine, Sem­yung Uni­ver­sity, ­Chungbuk, ­Korea
5 Koh­wang Med­ical ­Research Insti­tute, Col­lege of Med­i­cine, ­Kyung Hee Uni­ver­sity, ­Seoul, ­Korea


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Aim. ­Effect of tread­mill exer­cise on hip­po­campal ­cell pro­life­ra­tion ­under ­normal con­di­tions has ­been ­well doc­u­mented; how­ever, ­this ­effect ­under ­alcohol intox­i­ca­tion con­di­tions is not clar­i­fied, yet. In the ­present ­study, the ­effect of tread­mill exer­cise on ­cell pro­life­ra­tion in the den­tate ­gyrus in ­alcohol-intox­i­cated ­rats was inves­ti­gated.
­Methods. Experi­mental ­design: com­par­a­tive inves­ti­ga­tion on ­number of 5-­bromo-2’-deoxy­uri­dine (­BrdU)-pos­i­tive ­cells in the den­tate ­gyrus 8 ­days ­after com­mence­ment. Set­ting: ­animal labor­a­tory. Par­tic­i­pants: ­male ­Sprague-­Dawley ­rats of 5 ­weeks in age ­weighing 150±10 g. Inter­ven­tion: ani­mals ­were ­divided ­into 4 ­groups: the con­trol-­rest ­group, the con­trol-exer­cise ­group, the ­alcohol-­treated-­rest ­group, and the ­alcohol-­treated-exer­cise ­group. Ani­mals of the ­alcohol-­treated ­groups ­were ­injected intra­per­it­o­neally ­with ­alcohol (2 g/kg) ­once a day for 3 ­days. All ani­mals ­were ­injected ­BrdU (50 mg/kg) intra­per­it­o­neally, and ­rats of exer­cise ­groups ­were ­made to run on tread­mill for 30 min ­each day for 5 ­days fol­lowing ­alcohol admin­is­tra­tion. Meas­ures: ­mean ­number of ­BrdU-pos­i­tive ­cells in den­tate ­gyrus was ­observed via immu­no­his­to­chem­istry.
­Results. Tread­mill exer­cise sig­nif­i­cantly ­increased the ­number of ­BrdU-pos­i­tive ­cells in the den­tate ­gyrus. ­Also, treat­ment ­with ­alcohol for 3 ­days inhib­ited ­cell pro­life­ra­tion and tread­mill exer­cise alle­vi­ated ­alcohol-­induced inhi­bi­tion of new ­cell for­ma­tion.
Con­clu­sion. ­These ­results sug­gest the pos­sibility ­that tread­mill exer­cise may ­help in improve­ment fol­lowing ­alcohol-­induced ­brain ­damage.

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