Advanced Search

Home > Journals > The Journal of Sports Medicine and Physical Fitness > Past Issues > The Journal of Sports Medicine and Physical Fitness 2001 December;41(4) > The Journal of Sports Medicine and Physical Fitness 2001 December;41(4):513-20



A Journal on Applied Physiology, Biomechanics, Preventive Medicine,
Sports Medicine and Traumatology, Sports Psychology

Indexed/Abstracted in: Chemical Abstracts, CINAHL, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,111

Frequency: Monthly

ISSN 0022-4707

Online ISSN 1827-1928


The Journal of Sports Medicine and Physical Fitness 2001 December;41(4):513-20

    Original articles

Oxidative stress in hemodialyzed patients during exhausting exercise

Jiménez L., Lefèvre G. *, Richard R., Couderc R. *, Saint George M. **, Duvallet A., Rieu M.

From the Département de Physiologie de la Faculté de Médecine Cochin-Port-Royal (Université René Descartes) and Service d’Explorations Fonctionnelles et de Physiopathologie de l’Exercise Centre Hospitalier Cochin-Tarnier, Paris, France
* Service de Biochimie, Hôpital Tenon, Paris, France
** Service de Néphrologie et Dialyse Hôpital National de Saint Maurice, Maurice, France

Background. This ­study was ­designed to ­study the ­effect of an exhaust­ing exer­cise ­test on plas­ma lip­id per­ox­i­da­tion mark­er (mal­on­di­al­de­hyde, MDA) and on vita­min E lev­els in hemodialyzed ­patients (HD) com­pared to ­healthy con­trol sub­jects (HC).
Methods. Eight sed­en­tary chron­i­cal­ly HD, (39.0±10.8 ­years) and eight sed­en­tary HC (38.4±12.4 ­years) ­were stud­ied. Before exer­cise, the activ­ity of scav­en­ger ­enzymes [plas­ma and eryth­ro­cyte glu­tath­i­one per­ox­i­dase (GPX), and eryth­ro­cyte super­ox­ide dis­mu­tase (SOD)] was deter­mined. All sub­jects per­formed a symp­tom-lim­it­ed exer­cise ­test; res­pir­a­to­ry gas exchang­es ­were col­lect­ed on-­line and ­blood was sam­pled ­five min­ ­before exer­cise, at exhaus­tion and ­after 30 min­ of recov­ery.
Results. At ­rest, the activ­ity of plas­ma and eryth­ro­cyte GPX and eryth­ro­cyte SOD was sig­nif­i­cant­ly low­er in HD ­than in HC. Exercise pro­voked an ­increase of plas­ma MDA con­cen­tra­tion ­after recov­ery in HD ­patients, where­as our HC ­group ­show a ­decrease in MDA plas­ma lev­el imme­di­ate­ly ­after exer­cise, return­ing to the ­rest val­ues dur­ing recov­ery. Exercise ­induced no ­change of vita­min E con­cen­tra­tion in HD where­as in HC it ­increased dur­ing recov­ery.
Conclusions. Our ­results indi­cate ­that: 1) at ­rest: ­although hemo­di­a­lyzed ­patients ­showed low­er scav­en­ger ­enzymes activ­ity ­than HC sub­jects, ­there was no dif­fer­ence in MDA plas­ma lev­el ­between ­groups; 2) there is ­some evi­dence ­that phys­i­cal exer­cise con­trib­ute to oxi­da­tive ­stress dur­ing recov­ery in HD ­patients, and 3) exercise ­induced an ­increase in plas­ma vita­min E con­cen­tra­tion in ­healthy sub­jects.

language: English


top of page