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The Journal of Sports Medicine and Physical Fitness 2001 March;41(1):95-100

language: English

Postexercise proteinuria in humans and its adrenergic component

Poortmans J. R., Haggenmacher C., Vanderstraeten J.

From the ­Chimie Phys­io­lo­gique Institut Supér­ieur ­d’Education Phy­sique et de ­Kinésithérapie Université ­Libre de Brux­elles, Brux­elles (Bel­gium)


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Back­ground. Post­ex­er­cise pro­tei­nuria is a ­common phe­nom­enon ­depending on hypo­thet­ical mech­a­nisms ­such as the hemo­dy­namic ­system and its sym­pa­thetic com­po­nent. To ­test ­this hypoth­esis we admin­is­trated an α2-adre­nergic ago­nist (clon­i­dine) in ­order to ­reduce the cat­e­chol­a­mine ­response ­during exer­cise.
­Methods. Clon­i­dine (300 µg) and a pla­cebo, one ­week ­apart, ­were admin­is­trated ran­domly to ­nine ­healthy ­male sub­jects (23 yrs age) 2 hours ­prior to a max­imal exer­cise ­test on ­bicycle ergom­eter. ­Blood sam­ples and ­urine col­lec­tions ­were ­obtained at ­rest and ­after exer­cise. Lac­tate in ­plasma, crea­ti­nine and ­albumin in ­plasma and ­urine ­were ­assayed and ­their clear­ances ­were cal­cu­lated.
­Results. Post­ex­er­cise lac­tate was iden­tical ­under pla­cebo and clon­i­dine admin­is­tra­tion (10.1±1.0 ­versus 11.3±1.7 ­mmol.-1). It was ­observed ­that the clon­i­dine treat­ment ­induced a ­lesser post­ex­er­cise pro­tei­nuria (213±28 ­versus 298±55 µg.min-1) and albu­mi­nuria (71.8±16.3 ­versus 116.8±34.2 µg.min-1) ­when com­pared to the pla­cebo ­test. The post­ex­er­cise ­renal clear­ance of ­albumin did ­show a reduc­tion of 40% ­under the influ­ence of clon­i­dine.
Con­clu­sions. It may be ­argued ­that the cat­e­chol­a­mines are par­tially ­acting on the mech­a­nisms of the ­enhanced perme­ability of the glo­mer­ular mem­brane ­induced by stren­uous exer­cise.

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