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The Journal of Sports Medicine and Physical Fitness 2001 March;41(1):95-100

Copyright © 2009 EDIZIONI MINERVA MEDICA

language: English

Postexercise proteinuria in humans and its adrenergic component

Poortmans J. R., Haggenmacher C., Vanderstraeten J.

From the Chimie Physiologique Institut Supérieur d’Education Physique et de Kinésithérapie Université Libre de Bruxelles, Bruxelles (Belgium)


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Back­ground. Post­ex­er­cise pro­tei­nuria is a ­common phe­nom­enon ­depending on hypo­thet­ical mech­a­nisms ­such as the hemo­dy­namic ­system and its sym­pa­thetic com­po­nent. To ­test ­this hypoth­esis we admin­is­trated an α2-adre­nergic ago­nist (clon­i­dine) in ­order to ­reduce the cat­e­chol­a­mine ­response ­during exer­cise.
­Methods. Clon­i­dine (300 µg) and a pla­cebo, one ­week ­apart, ­were admin­is­trated ran­domly to ­nine ­healthy ­male sub­jects (23 yrs age) 2 hours ­prior to a max­imal exer­cise ­test on ­bicycle ergom­eter. ­Blood sam­ples and ­urine col­lec­tions ­were ­obtained at ­rest and ­after exer­cise. Lac­tate in ­plasma, crea­ti­nine and ­albumin in ­plasma and ­urine ­were ­assayed and ­their clear­ances ­were cal­cu­lated.
­Results. Post­ex­er­cise lac­tate was iden­tical ­under pla­cebo and clon­i­dine admin­is­tra­tion (10.1±1.0 ­versus 11.3±1.7 ­mmol.-1). It was ­observed ­that the clon­i­dine treat­ment ­induced a ­lesser post­ex­er­cise pro­tei­nuria (213±28 ­versus 298±55 µg.min-1) and albu­mi­nuria (71.8±16.3 ­versus 116.8±34.2 µg.min-1) ­when com­pared to the pla­cebo ­test. The post­ex­er­cise ­renal clear­ance of ­albumin did ­show a reduc­tion of 40% ­under the influ­ence of clon­i­dine.
Con­clu­sions. It may be ­argued ­that the cat­e­chol­a­mines are par­tially ­acting on the mech­a­nisms of the ­enhanced perme­ability of the glo­mer­ular mem­brane ­induced by stren­uous exer­cise.

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