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The Journal of Sports Medicine and Physical Fitness 1998 March;38(1):10-7

Copyright © 1998 EDIZIONI MINERVA MEDICA

language: English

Effects of prolonged strenuous endurance exercise on plasma myosin heavy chain fragments and other muscular proteins. Cycling vs running

Koller A. 1, Mair J. 2, Schobersberger W. 3, Wohlfarter Th. 4, Haids Ch. 5, Mayr M. 2, Villiger B. 6, Frey W. 6, Puschendorf B. 2

1 Department of Sports Medicine, University of Innsbruck, Austria; 2 Department of Medical Chemistry and Biochemistry, University of Innsbruck, Austria; 3 Clinic for Anaesthesia and General Intensive Care Medicine, University of Innsbruck, Austria; 4 Department of Internal Medicine, University of Innsbruck, Austria; 5 Department of Orthopaedic Surgery, University of Innsbruck, Austria; 6 Thurgauisch-Schaffhausische, Höhenklinik Davos, Switzerland


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Background. This ­study eval­u­ates crea­tine ­kinase, myo­sin ­heavy ­chain, and car­diac tro­po­nin ­blood lev­els fol­low­ing ­three ­types of exer­cise: 1) ­short-dis­tance ­uphill or down­hill run­ning; 2) ­alpine ultra­mar­a­thon; and 3) ­alpine ­long-dis­tance ­cycling.
Methods. Experimental ­design: Comparative ­field ­study; fol­low-up up to 10 ­days. Setting: Department of Sports Medicine. All bio­chem­i­cal mark­ers ­were ana­lysed at the Department of Medical Chemistry and Biochemistry. Patients or par­tic­i­pants: Subjects includ­ed ­healthy, ­trained ­males (N=53). All sub­jects ­were non­smok­ers and ­free ­from med­i­ca­tion ­prior to and dur­ing the ­study. Each vol­un­teer was an expe­ri­enced run­ner or ­cyclist, who had at ­least ­once suc­cess­ful­ly fin­ished the Swiss Alpine Marathon of Davos or the Ötztal-Radmarathon ­before. Interventions: Running or ­cycling. Measures: Plasma con­cen­tra­tions of crea­tine ­kinase, myo­sin ­heavy ­chain frag­ments and car­diac tro­po­nins ­were meas­ured to diag­nose skel­e­tal and car­diac mus­cle dam­age, respec­tive­ly.
Results. Skeletal mus­cle pro­tein ­release is mark­ed­ly dif­fer­ent ­between ­uphill and down­hill run­ning, ­with ­very lit­tle evi­dence for mus­cle dam­age in the ­uphill run­ners. There is con­sid­er­able mus­cle pro­tein leak­age in the ultra­mar­a­thon­ers (67 km dis­tance; 30 km down­hill run­ning). In con­trast, ­only mod­est ­amounts of skel­e­tal muscle dam­age are ­found ­after ­alpine ­long- di­stance ­cycling (230 km dis­tance).
Conclusions. This ­study ­proves ­that ­there is ­slow-­twitch skel­e­tal mus­cle ­fiber dam­age ­after pro­longed stren­u­ous endu­rance exer­cise and ­short-dis­tance down­hill run­ning. Exhaustive endu­rance exer­cise involv­ing down­hill run­ning and ­short-dis­tance down­hill run­ning ­lead to ­more pro­nounced inju­ry ­than stren­u­ous endu­rance exer­cise involv­ing con­cen­tric ­actions. From our ­results ­there is no rea­son for sug­gest­ing ­that pro­longed ­intense exer­cise may ­induce myo­car­dial inju­ry in symp­tom­less ath­letes with­out car­diac deseas­es.

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