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Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,6
Online ISSN 1827-1898
Dong GAO, Xianying MA
Department of Dermatology, Yantai Yuhuangding Hospital, Yantai, China
BACKGROUND: Recently, different studies suggested that the elevated serum concentration of lactate dehydrogenase (LDH) was associated with poor prognosis of melanoma. However, the results were controversial. Thus, we decided to perform a meta-analysis to assess the association between serum concentration of LDH and the overall survival (OS) of melanoma.
METHODS: Online electronic databases (PubMed, EMBASE, and Cochrane database) were searched. The association of LDH and the OS of melanoma was estimated by hazard ratio (HR) with its 95% confidence interval (CI).
RESULTS: A total of 13 eligible studies with 4036 patients met the inclusion criteria. LDH level was significantly associated with OS in melanoma patients (HR = 1.97, 95% CI 1.62 – 2.40, P <0.00001; I2=78%). In addition, LDH level was also significantly associated with OS in stage IV melanoma patients (HR = 1.99, 95% CI 1.59 – 2.50, P <0.00001; I2=79%). In the subgroup analysis by study design, a statistically significant association was found in retrospective cohort studies (HR = 2.31, 95% CI 1.18 – 4.51, P =0.01; I2=87%) and in prospective cohort studies (HR = 1.87, 95% CI 1.55 – 2.26, P<0.00001; I2=73%). In the subgroup analysis by sample size, LDH level was significantly associated with OS in large sample size studies (HR = 1.61, 95% CI 1.17 – 2.23, P =0.003; I2=73%) and small sample size studies (HR = 2.18, 95% CI 1.69 – 2.80, P <0.00001; I2=79%).
CONCLUSIONS: In conclusion, this meta-analysis suggested that high LDH level might be a predictor of poor prognosis of melanoma patients.