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Panminerva Medica 2013 September;55(3):297-302

language: English

Optimal conditions for “heat-conduct effect” in liver tissue during radiofrequency ablation

Jiang K., Su M., Liu Y., Zhao X., Liu J., Zhang W., Wang J., Dong J., Huang Z.

Institute and Hospital of Hepatobiliary Surgery Key Laboratory of Digital Hepatobiliary Surgery of Chinese PLA Chinese PLA Medical School Chinese PLA General Hospital, Beijing, China


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Aim: This study was conducted to optimize the “heat-conduct effect” to increase the efficacy of radiofrequency ablation (RFA) in the treatment of liver tumors.
Methods: To simulate the “heat-conduct effect” caused by RFA, isolated pig livers were heated by an inserted metal tube through which water with different incoming temperatures was passed. The tissue temperature was measured within 5- and 10-mm radiuses. Further, changes in color and morphology of the tissue were recorded.
Results: Using an incoming temperature of 70 °C, the effective ablation radius of 5 mm was achieved within 10 min. To expand the effective radius to 10 mm, the tube temperature needed to be maintained at above 80 °C for 40 min; alternatively, the tube temperature above 90 °C and heating time of 25 min were also sufficient.
Conclusion: To achieve the complete ablation in isolated liver within the 10 mm radius by “heat-conduct effect”, the temperature of the heating center should be maintained above 80 – 90 °C with the exposure time of 25-40 min.

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jiangk301@126.com