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A Journal on Internal Medicine
Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,6
Panminerva Medica 2011 September;53(3):185-91
Spray formulation of silver and hyaluronic acid in the treatment of superficial cutaneous ulcers of different etiopathogenesis: analysis of fifty-four clinical cases
Gazzabin L. 1, Bucalossi M. 2, Mariani F. 2, Serantoni S. 1 ✉
1 Department of General Surgery, Center of Diagnosis and Treatment of Vascular Ulcers, Villa Fiorita Clinic, Prato, Italy;
2 General Surgery Specialization School, Department of Surgery, University of Siena, Siena, Italy
AIM: The aim of this study was to assess a spray formulation containing colloidal silver and hyaluronic acid.
METHODS: Patients included in the study were divided in two separate groups: 30 patients had chronic wounds and 24 patients had superficial traumatic wounds. Applications were performed at intervals of 3-7 days, depending upon lesions characteristics. Subsequent improvements were evaluated at various intervals after enrollment. The lesion area and the rate of re-epithelialization were calculated, considering the time span and monitoring the patients for clinical signs of wound infection. Patients satisfaction and compliance were evaluated by a questionnaire aimed at assessing pain and ease of use of the device.
RESULTS: Chronic lesions were healed at week 12, with a high rate of closure observed at 6 weeks (70%). Furthermore, traumatic wounds healed at six weeks, with a substantial percentage of closure (80%) at three weeks. A good control of microbial contamination was evident in all the treated wounds; in no case other antimicrobial medications were used. Finally, patients favorably expressed compliance with regard to the spray formulation and ease of use.
CONCLUSION: This type of clinical approach seems to be a rational good choice to promote re-epithelialization of superficial cutaneous ulcers of different origins as well as control of bacterial infections.