Home > Journals > Panminerva Medica > Past Issues > Panminerva Medica 2010 June;52(2) > Panminerva Medica 2010 June;52(2):111-24

CURRENT ISSUE
 

ARTICLE TOOLS

Reprints

PANMINERVA MEDICA

A Journal on Internal Medicine


Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,6


eTOC

 

REVIEWS  REGENERATIVE MEDICINE


Panminerva Medica 2010 June;52(2):111-24

language: English

Graft-versus-Host Disease

Choi S., Reddy P.

Blood and Marrow Transplantation Program, Department of Internal Medicine, Division of Hematology/Oncology, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI, USA


PDF  


The number of allogeneic hematopoietic cell transplantations (HCT) continues to increase with more than 20000 allogeneic transplantations performed annually. The graft-versus-leukemia / tumor (GVL) effect during allogeneic HCT effectively eradicates many hematological malignancies. The development of novel strategies that use donor leukocyte infusions (DLI), nonmyeloablative conditioning and umbilical cord blood transplantation (UCB) have helped expand the indications for allogeneic HCT over the last several years, especially among older patients. Yet the major complication of allogeneic HCT, graft-versus-host disease (GVHD), remains lethal and limits its wider application. In this article we review current and recent advances made in understanding the complex and intricate pathophysiology of acute GVHD. GVH reaction is a consequence of interactions between the donor and host and their innate and adaptive immune responses. The fundamental interaction for induction of GVHD is the interaction of donor T cells with APCs and that this interaction is regulated positively or negatively by a plethora of cytokines, chemokines, and several immune cell subsets. In this article we review current and recent advances made in understanding of the cross-talk between these multiple cells and inflammatory molecules that have been implicated in the biology of GVHD.

top of page

Publication History

Cite this article as

Corresponding author e-mail

reddypr@med.umich.edu