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Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,6
Online ISSN 1827-1898
Leombruni P. 1, Picardi A. 2, Lavagnino L. 1, Orofino G. C. 3, Caramello P. 3, Morosini P. 2, Fassino S. 1
1 Psychiatry Section, Neuroscience Department, University of Turin, Turin, Italy;
2 Istituto Superiore di Sanità, Rome, Italy;
3 Division A, Infectious Diseases and Tropical Medicine, Amedeo di Savoia Hospital, Turin, Italy
AIM: The aim of the present study was to further test criterion validity and factorial validity of the McGIll Quality Of Life (MQOL) questionnaire, and to assess its reliability and sensitivity to clinical change in outpatients with HIV infection.
METHODS: The authors present a longitudinal study on a consecutive sample of 216 adults treated with HAART at the outpatient facility of an hospital-based tertiary care center in Italy. Patients completed the MQOL and the Beck Depression Inventory (BDI) both at baseline and follow-up assessments. Patients were classified into subgroups (improved, unchanged, worsened) based on change in BDI scores or CD4 count over time.
RESULTS: The pattern of correlation between MQOL subscales and the BDI was as hypothesised. A fairly simple factor structure emerged, with a striking resemblance between the factors and the MQOL subscales. The internal consistency of the MQOL and its subscales was high. The test-retest reliability in clinically unchanged patients was satisfactory. Sensitivity to change, as measured by Guyatt responsiveness statistic, was also satisfactory.
CONCLUSIONS. This study contributed to building evidence of reliability and validity for the MQOL questionnaire, which may be particularly useful to assess the so-called “existential” aspects of QOL that are particularly relevant for patients infected with HIV.