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Panminerva Medica 2008 June;50(2):105-18

Copyright © 2008 EDIZIONI MINERVA MEDICA

language: English

Recent advances in nuclear cardiology

Gutte H. 1, 2, Leth Petersen C. 3, Kjær A. 1, 2, Hesse B. 1

1 Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet Copenhagen University Hospital, Copenhagen, Denmark 2 Cluster for Molecular Imaging Faculty of Health Sciences University of Copenhagen, Copenhagen, Denmark 3 Department of Clinical Physiology and Nuclear Medicine, Frederiksberg Hospital, Denmark


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Nuclear cardiology is an essential part of functional, non-invasive, cardiac imaging. Significant advances have been made in nuclear cardiology since planar 201thallium (201TI) scintigraphy was introduced for the evaluation of left ventricular (LV) perfusion nearly 40 years ago. The use of nuclear cardiology has been steadily increasing over the last 20 years with important steps being the introduction of 99mtechnetium- (99mTc)-labelled perfusion radiotracers, the change from only planar to now much more single photon emission computed tomography (SPECT) and positron emission tomography (PET), electrocardiogram gating of nuclear perfusion imaging, and finally introducing nuclear hybrid imaging using either SPECT or PET together with either computed tomography or magnetic resonance imaging. The indications have extended from nearly only coronary artery diseases to several non-coronary cardiac diseases. The advances in nuclear cardiology are discussed under the four headlines of: 1) myocardial perfusion, 2) cardiac performance including LV and right ventricular (RV) function, 3) myocardial metabolism, and 4) experimental nuclear cardiology.

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