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A Journal on Internal Medicine

Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,6

Frequency: Quarterly

ISSN 0031-0808

Online ISSN 1827-1898


Panminerva Medica 2004 March;46(1):43-8


Prospects for cell-based therapies for liver disease

Min A. D. 1, Theise N. D. 1,2

1 Division of Digestive Diseases Department of Medicine Beth Israel Medical Center, New York, NY, USA
2 Division of Digestive Diseases Department of Pathology Beth Israel Medical Center, New York, NY, USA

Liver paren­chy­mal main­te­nance and regen­er­a­tion ­after inju­ry are phys­io­log­i­cal­ly sup­port­ed by 3 ­cell com­part­ments: ­mature liv­er ­cells, ­intra-­organ ­stem ­cells ­such as ­cells of the prox­i­mal bil­iary ­tree and per­i­duc­tal ­cells, and ­extra-­organ ­stem ­cells ­from the cir­cu­la­tion and the ­bone mar­row. In the lat­ter ­case, hepat­o­cyte der­i­va­tion ­from cir­cu­lat­ing ­cells (plas­tic­ity) can ­arise via ­direct trans­dif­fe­ren­ti­a­tion (­site spe­cif­ic, recep­tor/­ligand depen­dent) or by ­fusion of cir­cu­lat­ing ­cells ­with pre-exist­ing hep­a­toc­y­tes. Other non-phys­io­log­ic ­stem ­cells, ­such as mesen­chy­mal ­stem ­cells ­from the ­bone mar­row and embryon­ic ­stem ­cells, may be poten­tial­ly ­used in treat­ment of inher­it­ed and ­acquired liv­er dis­eas­es. This ­review ­updates our cur­rent under­stand­ing of ­these var­i­ous ­cell pop­u­la­tions and of pos­sible approach­es to ­their ­future ther­a­peu­tic ­uses in ­cell trans­plan­ta­tion, bio­ar­ti­fi­cial liv­er devic­es, cyto­kine/chem­o­kines manip­u­la­tion of phys­io­log­i­cal ­repair path­ways, and ­gene ther­a­py.

language: English


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