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A Journal on Internal Medicine

Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,6

Frequency: Quarterly

ISSN 0031-0808

Online ISSN 1827-1898


Panminerva Medica 2003 December;45(4):241-51


Adrenomedullin and endocrine disorders

Letizia C., Rossi G., Cerci S.

Department of Clinical Science University of Rome, “La Sapienza”, Rome, Italy

Adrenomedullin (AM) is a recent­ly dis­cov­ered ­potent vas­o­dil­a­to­ry pep­tide, orig­i­nal­ly iso­lat­ed in ­extracts of ­human phe­och­rom­o­cy­to­ma, ­with activ­ies includ­ing main­te­nance of car­di­o­vas­cu­lar and ­renal homeo­sta­sis ­through vas­o­dil­a­ta­tion, diu­re­sis and natriu­re­sis. Human AM con­sists of 52 ami­no ­acids ­with a 6-mem­ber ­ring struc­ture ­linked by a dis­ul­fide ­bond and ami­dat­ed ­COOH ter­mi­nal, ­which ­belongs to cal­cit­o­nin ­gene-relat­ed pep­tide (­CGRP) and amy­lin. The ­main ­sites of AM pro­duc­tion are the ­lungs, vas­cu­lar tis­sues (­both endo­the­lial and ­smooth mus­cle ­cells), ­heart, kid­ney, adren­al ­glands, pan­creat­ic ­islets, pla­cen­ta, ante­ri­or pitui­tary ­gland and gas­troin­tes­ti­nal neu­ro­en­do­crin­e ­sys­tem. Intravenous injec­tion of AM increas­es ­blood ­flow pre­dom­i­nant­ly in the tis­sues ­with the high­est AM expres­sion, sug­gest­ing ­that AM func­tions pri­mar­i­ly as a par­a­crine/auto­crine hor­mone, but it is ­also impor­tant as cir­cu­lat­ing hor­mone. The objec­tive of ­this ­review is to ana­lyze the evi­dence ­that AM may ­play a ­role in ­some endo­crine dis­or­ders.

language: English


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