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A Journal on Internal Medicine

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Panminerva Medica 2003 December;45(4):231-40

language: English

Epilepsy and adolescents

Verrotti A. 1, Di Corcia G. 1, Morgese G. 2, Trotta D. 1, Chiarelli F. 1

1 Section of Pediatrics Department of Medicine University of Chieti, Chieti, Italy
2 Department of Pediatrics University of Siena, Siena, Italy


Anticonvulsant (AEDs) ther­a­py in ado­les­cence is ­very dif­fi­cult ­because ­there is no-com­pli­ance in ­this spe­cial ­time of ­life. Many stud­ies ­show ­that the fac­tors ­that ­assured ­good com­pli­ance ­were ­good moti­va­tion, a ­good ther­a­peu­tic ­result, the sup­port of par­ents, med­i­cal and assis­tance per­son­nel and the pos­i­tive atti­tude to the dis­ease and its treat­ment. Moreover, in ­recent ­years, ­many stud­ies ­have ­shown the chang­es in endo­cri­nol­o­gy func­tion and ­weight chang­es in ado­les­cents ­after AEDs ther­a­py and ­after ­long ­term ther­a­py ­with val­proate (VPA), car­ba­maz­e­pine (CBZ), gab­a­pen­tin, fel­ba­mate and, topir­a­mate. Abnormalities ­include ­weight ­increase, ­weight ­loss, poly­cys­tic ovar­ies and ­bone dis­ease (oste­o­pe­nia/oste­o­por­o­sis, oste­om­a­la­cia, etc). Thyroid hor­mone con­cen­tra­tions are ­involved too. Some ­study ­report ­that the chil­dren treat­ed ­with CBZ may ­have sub­clin­i­cal ­signs of hypo­thy­roid­ism, and ­these chang­es are ­more evi­dent if CBZ is giv­en in asso­ci­a­tion ­with ­another ­drug for exam­ple ­with VPA.

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