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Panminerva Medica 2003 March;45(1):1-6

language: English

Statins and direct vascular actions

Mueck A. O., Seeger H.

Section of Endocrinology and Menopause Department of Obstetrics and Gynecology University of Tuebingen, Tuebingen, Germany


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Statins can ­exert ­many pleio­tropic ­effects ­beyond ­their cho­les­terol-low­ering ­action. These ­effects ­mainly influ­ence the vas­cular ­wall and may mod­ulate ben­e­fi­cially endo­the­lial func­tion, ather­o­gen­esis and ath­e­ros­cle­rotic ­plaque ­stability. Recent ­data sug­gest a pos­sible pos­i­tive ­effect of sta­tins on pre­ven­tion of oste­o­por­osis and can­cer­o­gen­esis. However, the mag­ni­tude of con­tri­bu­tion of ­these pleio­tropic ­statin ­effects to the reduc­tion of mor­bidity and mor­tality of car­di­o­vas­cular dis­eases ­remains to be deter­mined.

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