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A Journal on Internal Medicine
Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,6
Panminerva Medica 2003 March;45(1):1-6
Statins and direct vascular actions
Mueck A. O., Seeger H.
Section of Endocrinology and Menopause Department of Obstetrics and Gynecology University of Tuebingen, Tuebingen, Germany
Statins can exert many pleiotropic effects beyond their cholesterol-lowering action. These effects mainly influence the vascular wall and may modulate beneficially endothelial function, atherogenesis and atherosclerotic plaque stability. Recent data suggest a possible positive effect of statins on prevention of osteoporosis and cancerogenesis. However, the magnitude of contribution of these pleiotropic statin effects to the reduction of morbidity and mortality of cardiovascular diseases remains to be determined.