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Panminerva Medica 2002 September;44(3):243-51

Copyright © 2009 EDIZIONI MINERVA MEDICA

language: English

Phosphate measurements during hypokinesia and phosphate supplements in disclosing phosphate changes in hypokinetic subjects

Zorbas Y. G., Kakurin V. J., Kuznetsov N. A., Yarullin V. L., Andreyev I. D., Charapakhin K. P.

Higher Institute of Biochemistry, Gomel, Belarus *European Foundation of Environmental Sciences Athens, Greece


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Background. Hypokinesia (dimin­ished move­ment) ­induces sig­nif­i­cant phos­phate (P) ­change, how­ever, ­little is ­known ­about P reten­tion and P deple­tion ­during hypo­ki­nesia (HK). Measuring P reten­tion and P bal­ance ­during HK and P sup­ple­men­ta­tion, the objec­tive of ­this ­work was to dis­close ­whether HK ­could con­tribute to the ­decreased P reten­tion and con­se­quently to P deple­tion in ­normal sub­jects.
Methods. Studies ­were ­done ­during 30 ­days pre-HK ­period and 364 ­days HK ­period. Forty ­normal ­male indi­vid­uals ­aged, 25.3±6.4 ­years ­were ­chosen as sub­jects. They ­were ­divided ­equally ­into 4 ­groups: unsup­ple­mented ­active con­trol sub­jects (­UACS), unsup­ple­mented hypo­ki­netic sub­jects (­UHKS), sup­ple­mented ­active con­trol sub­jects (­SACS) and sup­ple­mented hypo­ki­netic sub­jects (­SHKS). Hypokinetic sub­jects ­were lim­ited to an ­average ­walking dis­tance of 0.5 km·day-l, ­while ­active con­trol sub­jects ­were ­kept on an ­average run­ning dis­tance of 9.6 km·day-l. Both, ­SHKS and ­SACS ­received ­daily 14 ­mmol dical­cium phos­phate per kg ­body ­weight.
Results. Negative P bal­ance, ­fecal P, uri­nary cal­cium (Ca) and P excre­tion, ­serum P and ­total (Cat) ­level ­increased sig­nif­i­cantly (p<0.05) ­while P reten­tion, ­serum ­intact para­thy­roid hor­mone (iPTH), 1,25 dihy­drox­y­vit­amin D (1,25 (OH)2 D3) and thy­ro­cal­cit­onin (TC) ­decreased sig­nif­i­cantly (p<0.05) in ­SHKS and ­UHKS com­pared ­with ­their pre-HK ­values and ­their respec­tive ­active con­trols (­SACS and ­UACS). However, neg­a­tive P bal­ance, P reten­tion inca­pacity, ­serum, ­fecal and uri­nary P ­level ­increased sig­nif­i­cantly (p<0.05) ­more in ­SHKS com­pared ­with ­UHKS. Fecal P ­loss, uri­nary P and Ca ­loss, ­serum P and Cat ­level, iPTH, TC and 1,25 (OH)2 D3 ­level, P reten­tion and P bal­ance ­change insig­nif­i­cantly (p>0.05) in ­SACS and ­UACS com­pared ­with ­their pre-HK ­level.
Conclusions. It was con­cluded ­that a sig­nif­i­cant P excre­tion in ­urine and ­feces in ­spite of neg­a­tive P bal­ance and P sup­ple­men­ta­tion may dem­on­strate ­reduced P reten­tion, ­while a sig­nif­i­cant ­increase of neg­a­tive P bal­ance may dem­on­strate P deple­tion. Clearly, P ­intake, regard­less of its low or ­higher ­dose, was sig­nif­i­cantly ­wasted ­during HK prob­ably due to the ­decreased ­ability of the ­body to ­retain P.

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