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A Journal on Internal Medicine
Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,6
Panminerva Medica 2002 June;44(2):129-33
Mg++SO4 treatment improves the hemodynamics following the acute myocardial ischemia and reperfusion
Karapinar K., Ulus A. T. *, Kaplan S. *, Tütün U. *, Saritas A. *, Aksöyek A. *, Apaydn N. **, Saritas Z. **, Katircioglu S. F. *
From the SSK Ankara Hospital, Ankara
*Cardiovascular Surgery, Department of Türkiye Yüksek Ihtisas Hospital of Ankara
**Veterinary Faculty of University of Ankara, Turkey
Background. The effect of Mg++SO4 on myocardial hemodynamics was investigated in this study.
Methods. Twelve dogs were entered in this research. Six dogs received Mg++SO4 and the remaining dogs were considered as controls. The amount of Mg++SO4 that was administered to the animals was 0.15 mmol/kg/hr each. The left anterior descending artery was occluded for a period of 1 hour and the drug was administered during reperfusion.
Results. Two hours after reperfusion, cardiac output was 1275±50 ml/min in the control group and 1475±25 ml/min in the Mg++SO4 group (p<0.05), pulmonary capillary wedge pressure was 18±3 mmHg in the control group and 12±2 mmHg in the Mg++SO4 group.
Conclusions. In this study it was shown that Mg++SO4 usage after 1 hour arterial occlusion and 2 hours reperfusion protects the heart from the adverse effects of ischemia/reperfusion and had a better central hemodynamics.