Advanced Search

Home > Journals > Panminerva Medica > Past Issues > Panminerva Medica 2002 June;44(2) > Panminerva Medica 2002 June;44(2):129-33



A Journal on Internal Medicine

Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,6

Frequency: Quarterly

ISSN 0031-0808

Online ISSN 1827-1898


Panminerva Medica 2002 June;44(2):129-33


Mg++SO4 treatment improves the hemodynamics following the acute myocardial ischemia and reperfusion

Karapinar K., Ulus A. T. *, Kaplan S. *, Tütün U. *, Saritas A. *, Aksöyek A. *, Apaydn N. **, Saritas Z. **, Katircioglu S. F. *

From the SSK Ankara Hospital, Ankara
*Cardiovascular Surgery, Department of Türkiye Yüksek Ihtisas Hospital of Ankara
**Veterinary Faculty of University of Ankara, Turkey

Background. The ­effect of Mg++SO4 on myo­car­dial hemo­dy­namics was inves­ti­gated in ­this ­study.
Methods. Twelve ­dogs ­were ­entered in ­this ­research. Six ­dogs ­received Mg++SO4 and the ­remaining ­dogs ­were con­sid­ered as con­trols. The ­amount of Mg++SO4 ­that was admin­is­tered to the ani­mals was 0.15 ­mmol/kg/hr ­each. The ­left ante­rior ­descending ­artery was ­occluded for a ­period of 1 ­hour and the ­drug was admin­is­tered ­during reper­fu­sion.
Results. Two ­hours ­after reper­fu­sion, car­diac ­output was 1275±50 ml/min in the con­trol ­group and 1475±25 ml/min in the Mg++SO4 ­group (p<0.05), pul­mo­nary cap­il­lary ­wedge pres­sure was 18±3 mmHg in the con­trol ­group and 12±2 mmHg in the Mg++SO4 ­group.
Conclusions. In ­this ­study it was ­shown ­that Mg++SO4 ­usage ­after 1 ­hour arte­rial occlu­sion and 2 ­hours reper­fu­sion pro­tects the ­heart ­from the ­adverse ­effects of ­ischemia/reper­fu­sion and had a ­better cen­tral hemo­dy­namics.

language: English


top of page