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A Journal on Internal Medicine

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Panminerva Medica 2002 June;44(2):93-7

language: English

Intrinsic angiotensin-generating system: its tissue specific functions and clinical implications

Leung P. S.

From the Department of Physiology, Faculty of Medicine The Chinese University of Hong Kong, Hong Kong


The clas­si­cal hor­mone angio­ten­sin II is ­derived ­from the cir­cu­lat­ing ­renin-angio­ten­sin ­system (RAS), ­which has a cru­cial ­role in the reg­u­la­tion of car­di­o­vas­cu­lar func­tion, elec­tro­lyte as ­well as ­water homeo­sta­sis. In addi­tion, numer­ous tis­sues/­organs pos­sess ­their own intrin­sic, angio­ten­sin-gen­er­at­ing ­systems ­that ­meet the ­needs spe­cif­ic for indi­vid­u­al tis­sues/­organs. The machin­ery ­could be oper­at­ed ­through the ­actions ­that add to, and/or dif­fer ­from, the cir­cu­lat­ing RAS. Of par­tic­u­lar inter­est in ­this con­text is the exis­tence of an intrin­sic RAS in ­such tis­sues as the pan­cre­as, epi­did­y­mis and carot­id ­body. There has ­been a ­steady ­stream of evi­dence to sug­gest ­that ­these intrin­sic RAS may ­have poten­tial ­roles in the main­te­nance of ­their tis­sue/organ spe­cif­ic func­tions. More intri­gu­ing­ly, alter­a­tions of ­such an intrin­sic RAS ­could be asso­ciat­ed ­with the phys­io­log­i­cal and path­o­phy­sio­log­i­cal ­aspects of the respec­tive tis­sue/­organ func­tions. Future tar­gets for the inter­ven­tion of the intrin­sic RAS, ­such as at the lev­els of pan­cre­as, epi­did­y­mis and carot­id ­body ­should ­have clin­i­cal impli­ca­tions for the man­age­ment of ­their respec­tive func­tions.

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