Total amount: € 0,00
HOW TO ORDER
A Journal on Internal Medicine
Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,6
Panminerva Medica 2001 September;43(3):145-8
HLA antigens in alkaptonuric patients
Aliberti G., Proietta M., Pulignano I., Tamburro M. L. *
From the Department of Clinical Sciences
*Department of General Surgery, Surgical Specialties and Organ Transplantation, “La Sapienza” University, Rome, Italy
Background. In alkaptonuric patients a disabilitating ochronotic arthropathy develops, due to the deposit of a pigmented polymer of homogentisic acid. Since in inherited diseases the clinical expressions may be multifactorial, involving genetic and environmental factors, where the HLA system may play a role, we studied HLA antigens in ochronotic patients.
Methods. The study was carried out in 21 members of three families of six ochronotic patients and in two isolated ochronotic patients. The HLA typing has been done testing for antigens from loci A, B and C, by international standard microlymphocytotoxicity method, and for loci DR and DQ, by fluorescence method on immunologically isolated cells by means of antibody-coated microspheres. The χ2 test was used for statistical analysis, with Yates correction due to the low number of observations.
Results. Despite the limited number of subjects, due to the rarity of the disease, a significantly higher prevalence of HLA-DR7 antigen was found in the alkaptonuric patients when compared to a general population (p<0.02), suggesting a possible association, while the prevalence of HLA A, B, C and DQ showed no significant differences.
Conclusions. It might play a role in the pathophysiology and in the clinical expression of the disease.