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A Journal on Internal Medicine
Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,6
Panminerva Medica 2001 June;43(2):115-8
Sexually and well-being in early menopause. Effect of transdermal estradiol therapy
Rigano A. *, Rigano M. **, Cancellieri F. **, Pullè C. **
From the Department of Obstestric and Gynecology
**Gynecologic and Obstetric Clinic University of Messina, Messina, Italy
Background. This study focus on the effect of 6 months transdermal estradiol therapy (TTS) on the sexual behaviour and the quality of life in early menopausal women, complaining of uncomfortable menopausal symptoms.
Methods. Three hundred and sixty-two postmenopausal women, aged 48-56, participated in this study. One hundred and seventy-one of them were given continuous solid matrix patch TTS 50 μg/day for 6 months. Sexual behaviour, menopausal symptoms and well-being were evaluated through a self-rating method. We used a structured questionnaire with three obligatory answers (less/same/more) for each question—sexual life, hot flushes, touchiness, insomnia, blood pressure, work willing, memory loss, well-being—, filled in by the women themselves or by the medical equipe after a telephone interview.
Results. Seventy five per cent of women aged 51-53 and 84% aged 54-56, who had been treated for 6 months with TTS showed a fall of sexual drive, if compared with, respectively, 62% and 48% of untreated subjects. Relief of hot flushes, touchiness and insomnia occurred in 80% of treated women, with slight differences among the various groups while 61% showed increase of well-being.
Conclusions. The results of our study demonstrate that continuous TTS for 6 months decreased sexual drive in 69% of women, improved menopausal symptoms in 80% women but increased well-being only in 61% of women. These differences suggest that women’s well-being does not seem linked only to the relief of menopausal symptoms and the impairment of their sexual life can play a negative role.