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A Journal on Internal Medicine

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Panminerva Medica 2001 June;43(2):85-7

language: English

Helicobacter pylori seroprevalence in hepatitis C virus positive patients with cirrhosis. The Como cross-sectional study

Spinzi G., Pellicano R. *, Minoli G., Terreni N., Cutufia M. A. **, Fagoonee S. **, Rizzetto M. *, Ponzetto A. *

From the Gastroenterology Unit, Valduce Hospital, Como, Italy
*Department of Gastro-Hepatology Molinette Hospital, Turin, Italy
**Department of Biology University of Turin, Turin, Italy


Background. Liver cir­rho­sis is a sig­nif­i­cant ­cause of ­death in Italy and one of the ­most fre­quent caus­es of hos­pi­tal­iza­tion. Acute pep­tic ­ulcer and ­upper gas­troin­tes­ti­nal bleed­ing report­ed­ly ­occur in ­over 15% of cir­rhot­ic ­patients. Since Helicobacter pylo­ri (H. pylo­ri) infec­tion strong­ly cor­re­lates ­with pep­tic ­ulcer, we ­sought to ascer­tain the ser­o­prev­a­lence of H. pylo­ri infec­tion in cir­rhot­ic ­patients.
Methods. In a ­cross-sec­tion­al ­study, we exam­ined 52 con­sec­u­tive ­patients (31 ­female and 21 ­male, age ­range 54-82, ­mean 68.7 ­years) suf­fer­ing ­from hep­a­titis C ­virus (HCV)-relat­ed cir­rho­sis attend­ing the Unit of Gastroenterology of the Valduce Hospital of Como (Italy).
Results. The prev­a­lence of anti­bod­ies ­against H. pylo­ri was 86.5% (45/52) in the cir­rhot­ics. Of ­female ­patients 28/31 (90.3%) ­were ser­o­pos­i­tive as com­pared to 17 of 21 (80.9%) of ­male ­patients.
Conclusions. The ­very ­high prev­a­lence of H. pylo­ri infec­tion may ­explain the fre­quent occur­rence of gas­trod­u­od­en­al ­ulcer in cir­rhot­ic ­patients.

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