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A Journal on Internal Medicine

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Panminerva Medica 2000 June;42(2):123-9

language: English

Effects of a short-term hypoenergetic diet on morphofunctional left ventricular parameters in centrally obese subjects. An echocardiographic study

Corrao S., Arnone S., Scaglione R., Amato V., Amico G., Licata A., Licata G.

From the Institute of Internal Medicine University of Palermo, Palermo, Italy


Background. We ­aimed to ­study cen­tral­ly ­obese sub­jects with­out oth­er dis­eas­es, to estab­lish wheth­er a ­short-­term hypo­en­er­get­ic bal­anced reg­i­men is ­able to pos­i­tive­ly mod­i­fy ­left ven­tric­u­lar (LV) pat­terns.
Methods. We stud­ied 32 ­obese sub­jects (out of 52 recruit­ed for ­this ­study) ­with cen­tral fat dis­tri­bu­tion and with­out asso­ciat­ed dis­eas­es. Each sub­ject had under­gone a mod­er­ate­ly hypo­en­er­get­ic ­diet for a ­four-­month fol­low-up peri­od and had a reg­u­lar ­loss in ­weight. Some rel­e­vant clin­i­cal and echoc­ar­di­o­graph­ic param­e­ters ­were eval­u­at­ed. Baseline ­data and ­those eval­u­at­ed at the end of the fol­low-up peri­od ­were ­used for out­come anal­y­sis.
Results. We ­found a con­sid­er­able reduc­tion in LV ­mass and oth­er LV struc­tu­ral param­e­ters includ­ing rel­a­tive ­wall thick­ness (RWT). Moreover, we ­found an improve­ment of ­both LV ejec­tion frac­tion and fill­ing param­e­ters. As ­regards the rela­tion ­ship ­between param­e­ter chang­es, LV ­mass was cor­re­lat­ed to LV inter­nal diam­e­ter and main­ly to LV ­wall thick­ness. LV ­mass ­change was ­also cor­re­lat­ed to a reduc­tion of dia­stol­ic BP and RWT. Only improve­ments in LV fill­ing ­were cor­re­lat­ed to WHR reduc­tion. None of the chang­es in car­diac var­i­ables result­ed sig­nif­i­cant­ly cor­re­lat­ed to BMI ­change. Other inter­est­ing cor­re­la­tions are report­ed in the ­text.
Conclusions. Our ­study ­points out ­that improve­ments in LV struc­ture and func­tion are rap­id­ly pos­sible ­with a mod­er­ate­ly hypo­en­er­get­ic reg­i­men in ­obese oth­er­wise ­healthy sub­jects. The ­main chang­es ­were ­those in LV ­wall thick­ness ­even if a ­more com­plex car­di­o­vas­cu­lar adjust­ment was rec­og­nised. All ­this ­could be ­very impor­tant to pos­sibly pre­vent ­future car­di­o­vas­cu­lar ­events (includ­ing ­heart fail­ure), so large­ly ­linked to obes­ity of cen­tral ­type.

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