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A Journal on Internal Medicine

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Panminerva Medica 2000 June;42(2):119-22

language: English

Iodinated contrast media induced oxidative stress status in patients undergoing urography

Rajbala, Sane A. S., Upadhyay A. R. *, Mishra V. V. **, Trivedi H. L. ***

From the Departments of Laboratory Medicine (Biochemistry), *Radiology **High Risk Pregnancy and ***Director Institute of Kidney Diseases and Research Centre
Civil Hospital Campus, Asarva, Ahmedabad, India


Background. The ­present inves­ti­ga­tion is an exten­sion of our ear­li­er ­work on oxi­dati­ve ­stress in a num­ber of clin­i­cal sit­u­a­tions and aware­ness of poten­tial tox­ic­ity of con­trast ­media. It was of inter­est to under­stand the rel­a­tive safe­ty (in ­terms of bal­ance ­between oxi­dants/anti­ox­i­dants) of the ­usage of iod­i­nat­ed con­trast ­media in urog­ra­phy.
Methods. Alterations in ser­um lev­els of oxi­dant lip­id per­ox­i­da­tion and prod­uct mal­on­di­al­de­hyde (MDA) and com­po­nents of ­anti-oxi­dant ­have ­been stud­ied in 125 ­patients (­with ­renal cal­cu­lus dis­ease) to under­go intra­ve­nous uro­graph­ic pro­ce­dure ­before and 3 ­hours fol­low­ing intra­ve­nous admin­is­tra­tion of Trivideo-400 (Iothalmate Sodium 40 ml: 18 gm Iodine) and ­results of ser­um lev­els of MDA (­nmol/ml), SOD (µ/ml), Vit-C and Vit-E (mg/dl) ­were ­also com­pared ­with 135 appro­pri­ate­ly age ­matched con­trols.
Results. The sali­ent fea­tures of the ­present inves­ti­ga­tion indi­cat­ed def­i­nite pat­tern viz. Significant ­rise in ser­um lev­els of oxi­dant MDA (4.35±2.05) and ­fall in SOD (3.04±1.04), Vit-C (0.55±0.17), Vit-E (0.67±0.20) in ­patients at pre-IVU ­stage in com­par­i­son ­with ­those of con­trols viz MDA (4.35±2.05), SOD (3.77±1.55), Vit-C (0.71±0.25) and Vit-E (0.80±0.30). There ­occurred fur­ther ele­va­tion in ser­um lev­els of MDA (5.28±2.48) and ­fall in SOD (3.07±0.97), Vit-C (0.52±0.16), Vit-E (0.66±0.19) show­ing no sig­nif­i­cant alter­a­tions 3 ­hours fol­low­ing intra­ve­nous IVU pro­ce­dure.
Conclusions. It is con­clud­ed ­that con­trast ­media ­induced chang­es did ­remain with­in tol­er­able phys­io­log­i­cal lim­its and no sig­nif­i­cant chang­es in ­anti-oxi­dant com­po­nents Vit-E and SOD ­were sug­ges­tive of rel­a­tive safe­ty of iodinated con­trast ­media ­usage.

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