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A Journal on Internal Medicine
Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,6
Panminerva Medica 2000 June;42(2):119-22
Iodinated contrast media induced oxidative stress status in patients undergoing urography
Rajbala, Sane A. S., Upadhyay A. R. *, Mishra V. V. **, Trivedi H. L. ***
From the Departments of Laboratory Medicine (Biochemistry), *Radiology **High Risk Pregnancy and ***Director Institute of Kidney Diseases and Research Centre
Civil Hospital Campus, Asarva, Ahmedabad, India
Background. The present investigation is an extension of our earlier work on oxidative stress in a number of clinical situations and awareness of potential toxicity of contrast media. It was of interest to understand the relative safety (in terms of balance between oxidants/antioxidants) of the usage of iodinated contrast media in urography.
Methods. Alterations in serum levels of oxidant lipid peroxidation and product malondialdehyde (MDA) and components of anti-oxidant have been studied in 125 patients (with renal calculus disease) to undergo intravenous urographic procedure before and 3 hours following intravenous administration of Trivideo-400 (Iothalmate Sodium 40 ml: 18 gm Iodine) and results of serum levels of MDA (nmol/ml), SOD (µ/ml), Vit-C and Vit-E (mg/dl) were also compared with 135 appropriately age matched controls.
Results. The salient features of the present investigation indicated definite pattern viz. Significant rise in serum levels of oxidant MDA (4.35±2.05) and fall in SOD (3.04±1.04), Vit-C (0.55±0.17), Vit-E (0.67±0.20) in patients at pre-IVU stage in comparison with those of controls viz MDA (4.35±2.05), SOD (3.77±1.55), Vit-C (0.71±0.25) and Vit-E (0.80±0.30). There occurred further elevation in serum levels of MDA (5.28±2.48) and fall in SOD (3.07±0.97), Vit-C (0.52±0.16), Vit-E (0.66±0.19) showing no significant alterations 3 hours following intravenous IVU procedure.
Conclusions. It is concluded that contrast media induced changes did remain within tolerable physiological limits and no significant changes in anti-oxidant components Vit-E and SOD were suggestive of relative safety of iodinated contrast media usage.