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A Journal on Internal Medicine

Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,6

Frequency: Quarterly

ISSN 0031-0808

Online ISSN 1827-1898


Panminerva Medica 2000 March;42(1):11-5


ATP-MgCl2 treatment after experimental acute myocardial ischemia and reperfusion

Katircioglu S. F., Ulus A. T., Saritas Z. *

From the Car­di­o­vas­cu­lar Sur­gery Depart­ment Türkiye Yüksek Ihti­sas Hos­pi­tal of Anka­ra
*Vet­e­ri­nary Facul­ty of Uni­ver­sity of Anka­ra, Tur­key

Back­ground. The ­effect of ATP-­MgCl2 on myo­car­dial metab­olism and hemo­dy­nam­ics was inves­ti­gat­ed in ­this ­study.
Meth­ods. ­Twelve ­dogs ­were ­entered in ­this ­research. Six ­dogs ­received ATP-­MgCl2 and the remain­ing ­dogs ­were con­sid­ered as con­trols. The ­amount of ATP and ­MgCl2 con­cen­tra­tion of ­this solu­tion is 100 µmol/ml ­each. The vol­ume admin­is­tered to the ani­mals dur­ing the aor­tic occlu­sion is 0.25 ml/kg/­hour; in the solu­tion are 100 µmol/ml ­dose ­each. The vol­ume admin­is­tered to the ani­mals dur­ing reper­fu­sion is 0.25 ml/kg/­hour. The ­left ante­ri­or descend­ing ­artery was occlud­ed for a peri­od of one ­hour and the ­drug was admin­is­tered dur­ing reper­fu­sion.
­Results. ­Three ­hours ­after reper­fu­sion, car­diac out­put was 1524±26 ml/min in the con­trol ­group and 1638±47 ml/min in the ATP-­MgCl2 ­group (p<0.05), pul­mo­nary cap­il­lary ­wedge pres­sure was 14±3 in the con­trol ­group and 8±2 in the ATP-­MgCl2 ­group. At the ­same ­time inter­val tis­sue ATP and lac­tate lev­el was 7±3, 1.3±0.4 in the con­trol ­group and 14±2, 0.0±0.2 in the ATP-­MgCl2 ­group respec­tive­ly (p<0.05).
Con­clu­sions. In ­this ­study we dem­on­strat­ed ­that ATP-­MgCl2 ­usage ­after one ­hour of arte­ri­al occlu­sion pro­tects the ­heart ­from the ­adverse ­effects of ische­mia/reper­fu­sion.

language: English


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