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Panminerva Medica 1999 December;41(4):363-6

language: English

Extralymphonodal Castleman’s dis­esase. A case ­report

Malaguarnera M., Restuccia N., Laurino A., Lo Manto P. C., Vinci E., Pistone G.

From the Institute of Internal Medicine and Geriatrics University of Catania, Catania, Italy


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Castleman’s dis­ease is a ­rare ­lymph ­node ­pathology char­ac­ter­ized by angio­fol­lic­ular hyper­plasia. There are two ­forms of the dis­ease: local­ized and ­systemic, ­with dif­ferent fea­tures, symp­toms and prog­nosis. Three are the his­to­log­ical ­types of dis­ease: ­plasma ­cell, hya­line-vas­cular and ­mixed var­i­ants. We ­report the ­case of a 65-year-old ­female ­affected by local­ized ­plasma ­cell var­iant of Castleman’s dis­ease. The sin­gu­larity of our ­case ­lies in its local­iza­tion on the ­breast and mono­clonal ­plasma ­cell pro­life­ra­tion ­inside the ­nodule.

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