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A Journal on Internal Medicine

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Panminerva Medica 1999 December;41(4):355-8

language: English

Takayasu’s arter­itis on ster­oid ther­a­py. Seven ­years fol­low-up

Del Corso L., Moruzzo D., Agelli M., Pentimone F.

From the Department of Internal Medicine University of Pisa, Pisa, Italy


The ­authors ­report a 7 ­year fol­low-up of Takayasu’s arter­itis (TA) ­type III, ­group 1, in a ­young Italian wom­an. At diag­no­sis, at the age of 25, the ech­o­tom­o­graph­ic and angio­graph­ic stud­ies ­showed nar­row sub­cla­vian arter­ies, nar­row abdom­i­nal aor­ta (diam­e­ter of 0.6-0.8 cm) ­below the ­renal arter­ies, ste­not­ic ­left com­mon carot­id and ­renal arter­ies, and occlud­ed ­upper mes­en­ter­ic ­artery. With ster­oid ther­a­py, (pred­ni­sone 50 mg/day per os), the eryth­ro­cyte sed­i­men­ta­tion ­rate (ESR) nor­mal­ized with­in 12 ­days. With a main­te­nance dos­age of 7.5 mg/day per os, the ­patient ­achieved remis­sion as doc­u­ment­ed by the ­absence of symp­toms, the per­sis­tent nor­mal­iza­tion of ESR, and the improv­ing of the diam­e­ter of the abdom­i­nal aor­ta (1.3-1.4 cm). On ster­oid ther­a­py, the ­patient had a nor­mal preg­nan­cy and deliv­ered a ­healthy ­baby ­girl. The dis­ease has ­been ­stable for sev­en ­years. Recently, dia­betes mel­lit­us ­occurred and it has ­been treat­ed ­with insu­lin ther­a­py. The ris­ing of ESR ­after taper­ing of ster­oid ther­a­py (pred­ni­sone 5 mg per os on alter­nate ­days) sug­gests an alter­na­tive treat­ment ­with a cyto­tox­ic ­agent.

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