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Home > Journals > Panminerva Medica > Past Issues > Panminerva Medica 1999 September;41(3) > Panminerva Medica 1999 September;41(3):247-51



A Journal on Internal Medicine

Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,6

Frequency: Quarterly

ISSN 0031-0808

Online ISSN 1827-1898


Panminerva Medica 1999 September;41(3):247-51


Markers of ­bone turn­over: consideration on ­their clin­i­cal appli­ca­tion in oste­o­por­o­sis

Cantatore F. P., Pipitone V.

From the Department of Rheumatology University of Bari, Bari, Italy

Osteoporosis is a con­di­tion in ­which an imbal­ance ­appears ­between ­bone resorp­tion and for­ma­tion, ­with ­bone resorp­tion exceed­ing for­ma­tion. However ­since the ­rate of ­bone ­loss var­ies sig­nif­i­cant­ly ­from one indi­vid­u­al to ­another result­ing in dif­fer­ent ­degrees of oste­o­por­o­sis, new bio­chem­i­cal tech­niques to meas­ure prod­ucts of ­bone resorp­tion and ­bone for­ma­tion ­have ­been ­used in the ­last ­years allow­ing us to eval­u­ate the ­degree of ­bone turn­over. Bone tis­sue is con­sti­tut­ed of an inor­gan­ic com­po­nent and an organ­ic ­matrix of col­la­gen and non­col­lag­e­nous pro­teins. Suitable ­bone mark­er ­should ­report the for­ma­tion and deg­ra­da­tion of all ­these con­stit­u­ents. Today mark­ers of ­bone for­ma­tion and mark­ers of ­bone resorp­tion are avail­able. According to ­recent lit­er­a­ture and per­son­al ­data assess­ment of ­bone metab­olism by the spe­cif­ic bio­chem­i­cal mark­ers is help­ful to ­select oste­op­o­rot­ic ­patients ­with ­high or low ­bone turn­over and ­these param­e­ters ­should be ­used to eval­u­ate wheth­er ­bone ­remains sen­si­tive to dif­fer­ent ther­a­pies.

language: English


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