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A Journal on Internal Medicine

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Panminerva Medica 1999 September;41(3):227-31

language: English

Haematologic pat­tern in ­healthy eld­er­ly sub­jects

Mal­a­guar­ne­ra M, Di Fazio I., Vincei E., Ben­ti­veg­na P., Mangione G., Roma­no M.

From the Department of Internal Medicine and Geriatrics University of Catania, Catania


Background. A ­more pro­longed ­life expec­tan­cy is asso­ciat­ed ­with an ­increased mor­bid­ity ­rate ­with ­marked alter­a­tions of phys­io­log­ic and meta­bol­ic func­tions in the ­body. The hae­mat­o­log­ic pat­tern can be mod­i­fied dur­ing age­ing ­because of ­reduced cel­lu­lar rep­li­ca­tion and ­enhanced fibro­sis in the ­bone mar­row. Nevertheless it is not ­clear wheth­er age­ing rep­re­sents the ­cause or the ­result of ­these phe­nom­e­na.
Methods. In ­order to eval­u­ate ­wide vari­a­tion of ­data on the hae­mat­o­log­ic pat­tern in eld­er­ly sub­jects, we stud­ied one hun­dred ­eight ­healthy sub­jects (27 ­males, 81 ­females; rang­ing ­from 50 to 99 ­years), liv­ing in ­their ­home.
Results. We ­observed a reduc­tion in ser­um ­iron and trans­fer­rin and an ­increase in ser­um fer­ri­tin lev­els dur­ing age­ing, ­with a con­se­quen­tial ­iron tis­sue ­stores ­increase.
Conclusions. Our ­data sug­gest­ed ­that senes­cence was asso­ciat­ed ­with an ­increased inci­dence of ane­mia, ­which can­not be con­sid­ered a nor­mal fea­ture of ­aging, the phy­si­cians ­must inves­ti­gate ­each ­cause of ane­mia in eld­er­ly sub­jects. Haematological pat­tern is in the nor­mal ­range in ­healthy eld­er­ly sub­jects, ­even if we ­found sig­nif­i­cant age-­linked ­changes. We con­clude ­that a pro­gres­sive impair­ment of ­bone mar­row func­tions is the ­most impor­tant fac­tor in deter­min­ing sig­nif­i­cant chang­es of hemat­o­poie­sis in ­healthy eld­er­ly sub­jects.

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