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A Journal on Internal Medicine

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Panminerva Medica 1999 September;41(3):207-15

language: English

The bio­log­i­cal ­effects of mag­net­ic stim­u­la­tion in epi­lep­tic ­patients

Anninos P. A., Tsagas N.*, Jacobson J. I.**, Kotini A.

From the Department of Medicine Demokrition University of Thrace Alexandroupolis, Greece
* Department of Electrical & Computer Engineering Demokrition University of Thrace, Xanthi, Greece
** Institute of Theoretical Physics and Advanced Studies for Biophysical Research, Jupiter, Florida, USA


Background. The magnetoencephalogram (MEG) is the mag­net­ic activ­ity emit­ted by the ­brain, ­which can be meas­ured ­using a superconductive quantum interference device (­SQUID). This is a total­ly non-inva­sive meth­od for local­iz­ing func­tion­al ­healthy, epi­lep­tic and oth­er CNS ­brain dis­or­ders.
Methods. Using the MEG ­brain ac­tivi­ty record­ed ­from epi­lep­tic ­patients we ­were ­able to ­obtain a map­ping tech­nique char­ac­ter­ized by the ISO-spectral amplitude of ­scalp dis­tri­bu­tion of the MEG Fourier pow­er spec­trum. In addi­tion, by uti­liz­ing the ­above record­ed MEG activ­ity we ener­gize an elec­tron­ic ­device, ­which ­emits ­back to the abnor­mal ­brain ­points of the epi­lep­tic ­patients mag­net­ic ­fields ­with prop­er fre­quen­cies and inten­sities.
Results. Using ­this meth­od we ­present ­here in ­more ­detail ­three ran­dom­ly select­ed epi­lep­tic ­patients in ­which appli­ca­tion of exter­nal mag­net­ic ­fields of low inten­sities and fre­quen­cies pro­duced a sub­stan­tial atten­u­a­tion of ­their abnor­mal ­brain activ­ity. Furthermore, we ­present a sta­tis­ti­cal anal­y­sis of 50 ran­dom­ly select­ed epi­lep­tic ­patients who under­went mag­net­ic stim­u­la­tion for the treat­ment of ­their sei­zures and we ­found ­that the anti­con­vul­sant ­response to mag­net­ic stim­u­la­tion was sta­tis­ti­cal­ly sig­nif­i­cant (χ2=6.55, df=1, p<0.02).
Conclusions. Our find­ings indi­cate ­that the use of low exter­nal mag­net­ic ­fields pro­duce sub­stan­tial atten­u­a­tion in sei­zure activ­ity in epi­lep­tic ­patients and there­fore it may ­open new ­ways in the ­future for man­age­ment of epi­lep­tic activ­ity.

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