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A Journal on Internal Medicine

Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,6

Frequency: Quarterly

ISSN 0031-0808

Online ISSN 1827-1898


Panminerva Medica 1999 March;41(1):45-53


Reactive oxy­gen spe­cies in male infer­til­ity. Review of lit­er­a­ture and per­son­al obser­va­tions

Conte G., Milardi D., De Marinis L., Mancini A.

From the Institute of Endocrinology The Catholic University School of Medicine, Rome, Italy

Reactive ­oxygen spe­cies, ­highly reac­tive mole­cules ­derived ­from the metab­olism of ­oxygen, ­play an impor­tant ­role in the metab­olism of sper­matozoa, ­related to the hyper­ac­ti­vated ­motility and acro­some reac­tion. Various ­studies ­have dem­on­strated ­that ­these mole­cules, ­because of ­their reac­tivity, can ­induce per­ox­i­da­tive ­damage on the ­cell, espe­cially on the ­lipid mem­branes. The sper­matozoa, ­owing to ­their struc­ture, ­appear to be ­very sen­si­tive to the oxi­da­tive ­insult. Various experi­mental ­data sus­tain the hypoth­esis ­that, ­when pro­duced in ­high ­amounts, reac­tive ­oxygen spe­cies can ­induce ­sperm ­damage and ­become poten­tially respon­sible for ­some ­forms of unex­plained infer­tility. The ­cells pos­sess var­ious mech­a­nisms of ­defense ­against the oxi­da­tive ­insult, ­mainly due to anti­ox­i­dant mole­cules. An anti­ox­i­dant treat­ment can pro­duce an improve­ment in sem­inal param­e­ters and ­sperm func­tion in ­vitro, and rep­re­sents a pos­sible ­form of ­care for ­selected ­forms of infer­tility.

language: English


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