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A Journal on Internal Medicine

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Panminerva Medica 1999 March;41(1):31-4

language: English

Effect of ­renal trans­plan­ta­tion (sur­gi­cal ­stress) on ser­um lev­els of oxi­dants and reduc­ing ­system

Rajbala A., Sane A. S., Shah P. R.*, Mishra V. V.**, Patel S. M.***, Shah S. A. ***, Shah V. R.°, Trivedi H. L.

From Depart­ment of Labor­a­to­ry Med­i­cine (Bio­chem­is­try) *Neph­rol­o­gy, **­High ­Risk Preg­nan­cy, ***Urol­o­gy °Anaesthe­sio­lo­gy Institute of Kidney Diseases and Research Centre, Ahmedabad, India


Back­ground. This ­study ­attempts to under­stand the cor­re­la­tion (if any) ­between sur­gi­cal ­stress of ­renal trans­plan­ta­tion and ser­um lev­els of pro-oxi­dant/anti­ox­i­dants.
Meth­ods. Twen­ty-­four ­ESRD ­patients hav­ing under­gone trans­plant sur­gery fol­lowed ­from day-1 to day-10 ­postsur­gery ­were inves­ti­gat­ed for ser­um lev­els of MDA, SOD, Vit. C and E. The ­drug reg­i­men ­received was immu­no­sup­press­ant, H2 block­ers and ­antihyper­ten­sives as per the sit­u­a­tion.
­Results. The typ­i­cal obser­va­tions indi­cat­ed ele­vat­ed ser­um lev­els of MDA ­from pre­op­er­a­tive ­stage reach­ing ­peak val­ue 24 hrs ­after sur­gery fol­lowed by a ­steady ­fall and achiev­ing min­i­ma on the 10th day. As ­regards anti­ox­i­dants ­enzyme SOD, Vit. C, Vit. E ­were low ­from pretrans­plant day reach­ing min­i­ma 24 ­hours post­op­er­a­tive­ly and return­ing to nor­mal ­from 7th day.
Con­clu­sions. The ­present inves­ti­ga­tion has amp­ly ­shown a typ­i­cal imbal­ance ­between pro-­ox­i­dant/anti­ox­i­dants ­from pre-trans­plant day up to 24 hrs and ­there ­after return­ing to nor­mal lev­el ­from 7th day sug­ges­tive of ­desired recov­ery and sur­gi­cal ­stress not a lim­it­ing fac­tor in way of ­health ­progress ­renal trans­plant. Die­tary ­intake of Vit. C and E in ­mega dos­es can be a ­good ther­a­peu­tic meas­ure.

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