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A Journal on Internal Medicine


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Panminerva Medica 1998 December;40(4):286-93

 ORIGINAL ARTICLES

Loss of endo­the­li­um medi­at­ed vas­cu­lar relax­a­tion as a ­response to var­i­ous clamp­ing pres­sures. Part II. ­Direct meas­ure­ments of clamp­ing pres­sures and scan­ning elec­tron micro­scope ­study

Gersak B., Trobec R.*, Psenicnik M.**

From the Depart­ment of Car­di­o­vas­cu­lar Sur­gery, Med­i­cal Cen­ter Ljubl­ja­na
* Jozef Stefan Institute, Ljubljana
** Institute for Human Biology, School of Medicine, Ljubljana, Slovenia

Back­ground. We ­used nov­el equip­ment for meas­ur­ing the ­direct tip pres­sure (P) of a ­clamp arm on the ves­sel ­wall and stud­ied the rela­tion­ship ­between endo­the­lial inju­ries and var­i­ous clamp­ing pres­sures.
Meth­ods. A ­strain ­gauge was ­applied to the sur­gi­cal ­clamp arm and con­nect­ed via ampli­fi­er to a 12-bit ana­logue-dig­i­tal con­vert­er on a PC - ­MSDOS com­put­er. In the on-­line in ­vivo meas­ure­ments on rat tho­rac­ic aor­ta a momen­tary ­peak clamp­ing pres­sure (­MPCP) as ­well as the low­er sta­tion­ary clamp­ing pres­sure (SCP) was ­defined. Clamp­ing forc­es of two ­clamps com­mon­ly ­used in car­di­o­vas­cu­lar micro­sur­gery ­were test­ed in the experi­ment on rat tho­rac­ic aor­tas: ­clamp A had the tip pres­sure p=0.60 N/mm2 and ­clamp B p=5.16 N/mm2. ­After 15 min­utes of occlu­sion, the tho­rac­ic aor­ta was ­excised and scan­ning elec­tron micros­co­py stud­ies for aor­tas ­clamped ­with ­clamp A and ­clamp B ­were per­formed.
­Results. ­Great endo­the­lial lac­er­a­tions ­with com­plete dis­rup­tion of the endo­the­lial ­layer in the ­rings ­clamped ­with the ­clamp B ­were ­seen, but no dis­rup­tion in ­rings ­clamped ­with ­clamp A.
Con­clu­sions. The clamp­ing ves­sel ­wall inju­ries, par­tic­u­lar­ly in endo­the­lial ­layers, ­depend on the momen­tary ­peak clamp­ing pres­sure as ­well on the low­er sta­tion­ary clamp­ing pres­sure.

language: English


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