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A Journal on Internal Medicine
Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,6
Panminerva Medica 1998 September;40(3):244-6
Prophylaxis of cystine calculi by low dose of α−mercapto-propionyl-glycine administered every other day
Berio A., Piazzi A.
From the Chair of Pediatrics, University of Genoa Institute G. Gaslini, Genoa, Italy
In a case of typical cystinuria type I with left kidney hypoplasia and bilateral calculosis, calculi were dissolved by means of α-mercapto-propionyl-glycine and prophylaxis of the calculosis was performed by the same drug continuously administered in two divided doses (10-4 mg·kg-1·day-1) for 9 years, without urolithiasis. Then, the α-mercapto-propionyl-glycine every other day in one dose, 4 mg·kg-1·day-1, for two years was administered without calculosis. The arbitrary discontinuation of the drug by the patient was followed after 6 months from a right ureteral calculosis with transitory renal insufficiency. In our case the administration of a low dose of α-mercapto-propionyl-glycine every other day was useful in cystine calculosis prophylaxis.