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Panminerva Medica 1998 September;40(3):223-5

Copyright © 2000 EDIZIONI MINERVA MEDICA

language: English

Time length of negativization of hCG serum values after either surgical or medical treatment of ectopic pregnancy

Colacurci N., De Franciscis P., Zarcone R., Fortunato N., Passaro M., Mollo A.*, Russo G.

From the Department of Gynecology and Obstetrics School of Medicine, Second University of Naples, Italy * Ist Department of Ginecology and Obstetrics Medical School, Federico II University, Naples, Italy


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Objective. The ­aim of ­this ­study ­was to com­pare ­the ­time ­length ­until ­the ­human chor­ion­ic gon­a­dot­ro­pin tit­er ­became neg­a­tive ­after med­i­cal or sur­gi­cal treat­ment of ectop­ic preg­nan­cy.
Experimental ­design. Prospective, ran­dom­ized ­study.
Partecipants ­and inter­ven­tions. We com­pared ­time to res­o­lu­tion in 30 cas­es of ­tubal preg­nan­cies suc­cess­ful­ly treat­ed, 15 under­went lapar­os­cop­ic lin­e­ar sal­pin­gos­to­my (­group 1) ­and 15 med­i­cal treat­ment ­with sin­gle-­ose methot­rex­ate (group 2). The ­patients of ­both ­groups ­had no mean­ing­ful dif­fer­enc­es of ­age, ges­ta­tion­al ­age ­and ­human chor­ion­ic gon­a­dot­ro­pin ­mean val­ues.
Measures. During ­the fol­low-up ­human chor­ion­ic gon­a­dot­ro­pin ser­um val­ues ­were ­obtained eve­ry ­two ­days ­until ­the tit­er ­was neg­a­tive.
Results. The ­time to res­o­lu­tion ­was 33.6 ± 6.6 ­days in ­group 1, 31.5 ± 7.8 in ­group 2 ­with no sta­tis­ti­cal­ly mean­ing­ful dif­fer­enc­es.
Conclusion. The ­data, com­par­able ­with ­results ­obtained by lapar­os­cop­ic treat­ment, sug­gest ­that ­human chor­ion­ic gon­a­dot­ro­pin val­ue ­becomes neg­a­tive inde­pen­dent­ly of ­type of treat­ment ­and resid­u­al troph­o­blast.

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